Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint".
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerA positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationMammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failureRegulation of cell cycle by the anaphase spindle midzoneCellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationCentrosomes, chromosome instability (CIN) and aneuploidyDNA damage associated with mitosis and cytokinesis failureCell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Fibronectin assembly in the crypts of cytokinesis-blocked multilobular cells promotes anchorage-independent growthQuantitative analysis of cytokinesis in situ during C. elegans postembryonic developmentKinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzoneCDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following MitosisTranscriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53Premature senescence and increased TGFβ signaling in the absence of Tgif1.p53 suppresses tetraploid development in miceTriggering p53 after cytokinesis failureCell division and cell survival in the absence of survivin.Extra centrosomes and/or chromosomes prolong mitosis in human cellsNucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis.Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 inductionA non-genetic route to aneuploidy in human cancersInterphase cytofission maintains genomic integrity of human cells after failed cytokinesis.Failure of cell cleavage induces senescence in tetraploid primary cells.Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells.A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells.Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation.p53 suppresses structural chromosome instability after mitotic arrest in human cells.Generating chromosome instability through the simultaneous deletion of Mad2 and p53.Link between DNA damage and centriole disengagement/reduplication in untransformed human cells.p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cellsEssential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression.Apoptosis regulation in tetraploid cancer cells.Elucidation of proliferative capability of mononuclear tetraploid cells, emerging spontaneously from diploid cells, using image cytometry and fluorescence in situ hybridization.Activation of miR-9 by human papillomavirus in cervical cancer.Centriole age underlies asynchronous primary cilium growth in mammalian cells.Genomic Instability Induced By Human Papillomavirus Oncogenes.Role of Cdk1 in the p53-independent abrogation of the postmitotic checkpoint by human papillomavirus E6Repeated cleavage failure does not establish centrosome amplification in untransformed human cells.Cell-to-cell variability of alternative RNA splicing.
P2860
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P2860
Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint".
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Cell cycle progression after c ...... ss a "tetraploidy checkpoint".
@ast
Cell cycle progression after c ...... ss a "tetraploidy checkpoint".
@en
type
label
Cell cycle progression after c ...... ss a "tetraploidy checkpoint".
@ast
Cell cycle progression after c ...... ss a "tetraploidy checkpoint".
@en
prefLabel
Cell cycle progression after c ...... ss a "tetraploidy checkpoint".
@ast
Cell cycle progression after c ...... ss a "tetraploidy checkpoint".
@en
P2860
P356
P1476
Cell cycle progression after c ...... ss a "tetraploidy checkpoint".
@en
P2093
Greenfield Sluder
Yumi Uetake
P2860
P304
P356
10.1083/JCB.200403014
P407
P577
2004-06-01T00:00:00Z