The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
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Kinesin-5: cross-bridging mechanism to targeted clinical therapyThe NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formationPathway of ATP hydrolysis by monomeric kinesin Eg5Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitroSmall-molecule and mutational analysis of allosteric Eg5 inhibition by monastrolProphase microtubule arrays undergo flux-like behavior in mammalian cellsKinesin 5-independent poleward flux of kinetochore microtubules in PtK1 cells.Dynamic partitioning of mitotic kinesin-5 cross-linkers between microtubule-bound and freely diffusing states.Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle.Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosisA model for the regulatory network controlling the dynamics of kinetochore microtubule plus-ends and poleward flux in metaphaseSpindle fusion requires dynein-mediated sliding of oppositely oriented microtubulesFast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules.Lamin B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assemblyEssential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface.Kif11 dependent cell cycle progression in radial glial cells is required for proper neurogenesis in the zebrafish neural tube.Kinetochore-microtubule stability governs the metaphase requirement for Eg5.Physical basis of spindle self-organizationKinesin-5 is a microtubule polymerase.Kinesin-5 inhibitor resistance is driven by kinesin-12Bipolarization and poleward flux correlate during Xenopus extract spindle assembly.The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.Kinesin-5 motors are required for organization of spindle microtubules in Silvetia compressa zygotes.A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly.The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations.Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindlesDirectly probing the mechanical properties of the spindle and its matrix.Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindlesMicroneedle-based analysis of the micromechanics of the metaphase spindle assembled in Xenopus laevis egg extractsTPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts.A computational model predicts Xenopus meiotic spindle organization.Kinesin molecular motor Eg5 functions during polypeptide synthesis.Eg5 steps it up!Mechanism for Anaphase B: Evaluation of "Slide-and-Cluster" versus "Slide-and-Flux-or-Elongate" Models.Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysisLoad-dependent release limits the processive stepping of the tetrameric Eg5 motor.CLASP fluxes its mitotic muscles.A new method reveals microtubule minus ends throughout the meiotic spindle.
P2860
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P2860
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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name
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
@ast
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
@en
type
label
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
@ast
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
@en
prefLabel
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
@ast
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
@en
P2093
P2860
P356
P1476
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
@en
P2093
Aaron C Groen
David T Miyamoto
Kendra S Burbank
Timothy J Mitchison
Zachary E Perlman
P2860
P304
P356
10.1083/JCB.200407126
P407
P577
2004-12-01T00:00:00Z