Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.
about
Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosisLatent TGF-β-binding proteinsMatrix control of transforming growth factor-β functionPulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesisA rapid and sensitive bioassay to measure bone morphogenetic protein activity.The Role of the Molecular Clock in Skeletal Muscle and What It Is Teaching Us About Muscle-Bone Crosstalk.Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation.An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment.A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodelingBiological Significance of Local TGF-β Activation in Liver Diseases.Genotype-Specific Interaction of Latent TGFβ Binding Protein 4 with TGFβ.Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosisMolecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis.Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition.Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.Modifying muscular dystrophy through transforming growth factor-β.Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity.Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice.TB domain proteins: evolutionary insights into the multifaceted roles of fibrillins and LTBPs.New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis.Extracellular vesicles shed by glioma cells: pathogenic role and clinical value.Association of chromosome 19 to lung cancer genotypes and phenotypes.Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β SignalingTGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment.Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease.Targeting latent TGFβ release in muscular dystrophy.Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos.Apoptosis of human endothelial cells is accompanied by proteolytic processing of latent TGF-beta binding proteins and activation of TGF-beta.Attenuation of bleomycin-induced pulmonary fibrosis by follistatin.Latent transforming growth factor binding protein 4 (LTBP4) is downregulated in mouse and human DCIS and mammary carcinomas.
P2860
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P2860
Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Disruption of LTBP-4 function ...... s BMP-4 signaling in the lung.
@ast
Disruption of LTBP-4 function ...... s BMP-4 signaling in the lung.
@en
type
label
Disruption of LTBP-4 function ...... s BMP-4 signaling in the lung.
@ast
Disruption of LTBP-4 function ...... s BMP-4 signaling in the lung.
@en
prefLabel
Disruption of LTBP-4 function ...... s BMP-4 signaling in the lung.
@ast
Disruption of LTBP-4 function ...... s BMP-4 signaling in the lung.
@en
P2093
P2860
P356
P1476
Disruption of LTBP-4 function ...... s BMP-4 signaling in the lung.
@en
P2093
Anja Sterner-Kock
Anna Kantola
Frank Wempe
Harald von Melchner
Jorma Keski-Oja
Katri Koli
Martina Komor
Wolf-K Hofmann
P2860
P304
P356
10.1083/JCB.200403067
P407
P577
2004-10-04T00:00:00Z