Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles.
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Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesisReconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperonesPhosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusionHOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusionRegulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.Phosphatidic Acid Sequesters Sec18p from cis-SNARE Complexes to Inhibit PrimingRole of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae.HOPS proofreads the trans-SNARE complex for yeast vacuole fusionPurification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.The yeast ATP-binding cassette (ABC) transporter Ycf1p enhances the recruitment of the soluble SNARE Vam7p to vacuoles for efficient membrane fusion.A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast.The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain.The HOPS/Class C Vps Complex Tethers High-Curvature Membranes via a Direct Protein-Membrane Interaction.Yeast lipin 1 orthologue pah1p regulates vacuole homeostasis and membrane fusion.Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification.Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast.The specificity of SNARE pairing in biological membranes is mediated by both proof-reading and spatial segregationBem1p is a positive regulator of the homotypic fusion of yeast vacuoles.In vitro assay using engineered yeast vacuoles for neuronal SNARE-mediated membrane fusion.Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion.The yeast vacuolar Rab GTPase Ypt7p has an activity beyond membrane recruitment of the homotypic fusion and protein sorting-Class C Vps complexPhosphorylation of the effector complex HOPS by the vacuolar kinase Yck3p confers Rab nucleotide specificity for vacuole docking and fusion.Requirement for Golgi-localized PI(4)P in fusion of COPII vesicles with Golgi compartmentsDirect imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells.Cortactin promotes exosome secretion by controlling branched actin dynamicsHow and why intralumenal membrane fragments form during vacuolar lysosome fusion.Osmotic regulation of Rab-mediated organelle dockingDynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3.Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion.HOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly.A lipid-anchored SNARE supports membrane fusionA distinct tethering step is vital for vacuole membrane fusion.Phosphoinositides function asymmetrically for membrane fusion, promoting tethering and 3Q-SNARE subcomplex assembly.Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast.Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes.Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion.Astrocytes release D-serine by a large vesicleYeast-to-hyphal transition triggers formin-dependent Golgi localization to the growing tip in Candida albicans.Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis.Examination of Sec22 Homodimer Formation and Role in SNARE-dependent Membrane Fusion
P2860
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P2860
Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Interdependent assembly of spe ...... ing domain of docked vacuoles.
@ast
Interdependent assembly of spe ...... ing domain of docked vacuoles.
@en
type
label
Interdependent assembly of spe ...... ing domain of docked vacuoles.
@ast
Interdependent assembly of spe ...... ing domain of docked vacuoles.
@en
prefLabel
Interdependent assembly of spe ...... ing domain of docked vacuoles.
@ast
Interdependent assembly of spe ...... ing domain of docked vacuoles.
@en
P2093
P2860
P356
P1476
Interdependent assembly of spe ...... ing domain of docked vacuoles.
@en
P2093
Alexey J Merz
Nathan Margolis
Rutilio A Fratti
William Wickner
Youngsoo Jun
P2860
P304
P356
10.1083/JCB.200409068
P407
P577
2004-12-01T00:00:00Z