Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.
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The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherinThe MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formationHuman homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cellsDeregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinomaScrib regulates PAK activity during the cell migration processDensin-180: revised membrane topology, domain structure and phosphorylation statusPDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target ProteinsInterdomain interface-mediated target recognition by the Scribble PDZ34 supramoduleJunctional recruitment of mammalian Scribble relies on E-cadherin engagementZDHHC7-mediated S-palmitoylation of Scribble regulates cell polaritySignaling pathways in cell polarity.The Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks retrieval of E-cadherin to the Golgi.Immature T-cell clustering and efficient differentiation require the polarity protein Scribble.Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.The cell polarity protein Scrib functions as a tumor suppressor in liver cancer.Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovary.Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancerNon-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor modelPolarity protein complex Scribble/Lgl/Dlg and epithelial cell barriersLoss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signalingAbnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.Mutations in planar cell polarity gene SCRIB are associated with spina bifida.Spectrin binding motifs regulate Scribble cortical dynamics and polarity function.The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures.SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasiaThe polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin ReceptorPhosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase.Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial MorphogenesisUsing Drosophila melanogaster to map human cancer pathways.A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation.Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90.Regulation of actin dynamics and protein trafficking during spermatogenesis--insights into a complex process.The PIX-GIT complex: a G protein signaling cassette in control of cell shapeControl of tumourigenesis by the Scribble/Dlg/Lgl polarity module.Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarityDrosophila cancer models.The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis.NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling.
P2860
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P2860
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Domains controlling cell polar ...... ila tumor suppressor Scribble.
@ast
Domains controlling cell polar ...... ila tumor suppressor Scribble.
@en
type
label
Domains controlling cell polar ...... ila tumor suppressor Scribble.
@ast
Domains controlling cell polar ...... ila tumor suppressor Scribble.
@en
prefLabel
Domains controlling cell polar ...... ila tumor suppressor Scribble.
@ast
Domains controlling cell polar ...... ila tumor suppressor Scribble.
@en
P2093
P2860
P356
P1476
Domains controlling cell polar ...... ila tumor suppressor Scribble.
@en
P2093
Cynthia P Hsu
David Bilder
Heather Dionne
Jennifer Zeitler
P2860
P304
P356
10.1083/JCB.200407158
P407
P577
2004-12-01T00:00:00Z