2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. - Wikidata - wikimedia - TriplyDB

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

http://www.wikidata.org/entity/Q36328206

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Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives Oncometabolites: Unconventional triggers of oncogenic signalling cascades 2-Hydoxyglutarate: D/Riving Pathology in gLiomaS Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells Regulation of the H+-ATP synthase by IF1: a role in mitohormesis.A quantitative transcriptomic analysis of the physiological significance of mTOR signaling in goat fetal fibroblasts Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique.Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.Emerging applications of metabolomics in drug discovery and precision medicine.Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.DNA methylation in adult diffuse gliomas.Glutamate and α-ketoglutarate: key players in glioma metabolism.L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration.The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity.Current Perspective in the Discovery of Anti-aging Agents from Natural Products.The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies.Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice.Signaling pathways involved in the regulation of mRNA translation.The Role of Mitochondrial H+-ATP Synthase in Cancer.D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization.Biological Role and Therapeutic Potential of IDH Mutations in Cancer.Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

http://www.wikidata.org/entity/Q36328206

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

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J.CMET.2015.06.009

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Cell Metabolism

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

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Albert Lai

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Daniel Braas

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David A Nathanson

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Gang Deng

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Heejun Hwang

http://www.w3.org/2001/XMLSchema#string

Jing Huang

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Kym F Faull

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Lisa Ta

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Meisheng Jiang

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Melody Y Pai

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P2860

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Understanding the Warburg effect: the metabolic requirements of cell proliferation

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

An integrated genomic analysis of human glioblastoma multiforme

IDH1 and IDH2 mutations in gliomas

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

On the Origin of Cancer Cells

IDH2 mutations in patients with D-2-hydroxyglutaric aciduria

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508-515

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10.1016/J.CMET.2015.06.009

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3

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22

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Heather R Christofk

Robert M. Prins

Farbod Fazlollahi

Laurent Vergnes

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2015-07-14T00:00:00Z

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280220177

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