Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C
about
The Importance of Intrinsically Disordered Segments of Cardiac Troponin in Modulating Function by Phosphorylation and Disease-Causing MutationsRegulatory domain of troponin moves dynamically during activation of cardiac muscleComputational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.Ca2+-induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch.Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulationsMultiscale Estimation of Binding Kinetics Using Brownian Dynamics, Molecular Dynamics and Milestoning.Molecular Basis of S100A1 Activation at Saturating and Subsaturating Calcium Concentrations.Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations.Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study.Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC.Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders.SEEKR: Simulation Enabled Estimation of Kinetic Rates, A Computational Tool to Estimate Molecular Kinetics and Its Application to Trypsin-Benzamidine Binding.Troponin structure: its modulation by Ca(2+) and phosphorylation studied by molecular dynamics simulations.
P2860
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P2860
Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Long-timescale molecular dynam ...... ydrophobic patch in troponin C
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Long-timescale molecular dynam ...... ydrophobic patch in troponin C
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type
label
Long-timescale molecular dynam ...... ydrophobic patch in troponin C
@ast
Long-timescale molecular dynam ...... ydrophobic patch in troponin C
@en
prefLabel
Long-timescale molecular dynam ...... ydrophobic patch in troponin C
@ast
Long-timescale molecular dynam ...... ydrophobic patch in troponin C
@en
P2860
P1433
P1476
Long-timescale molecular dynam ...... ydrophobic patch in troponin C
@en
P2093
Peter M Kekenes-Huskey
Steffen Lindert
P2860
P304
P356
10.1016/J.BPJ.2012.08.058
P407
P577
2012-10-16T00:00:00Z