Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.
about
Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides; and generation of a new to nature bromo-natural product and its diversification in water.Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity.Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan SynthaseA Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan AnaloguesDirected Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
P2860
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P2860
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.
description
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name
Directed evolution of the tryp ...... tulates allosteric activation.
@ast
Directed evolution of the tryp ...... tulates allosteric activation.
@en
type
label
Directed evolution of the tryp ...... tulates allosteric activation.
@ast
Directed evolution of the tryp ...... tulates allosteric activation.
@en
prefLabel
Directed evolution of the tryp ...... tulates allosteric activation.
@ast
Directed evolution of the tryp ...... tulates allosteric activation.
@en
P2860
P50
P356
P1476
Directed evolution of the tryp ...... tulates allosteric activation.
@en
P2093
Andrew R Buller
Michael Herger
P2860
P304
14599-14604
P356
10.1073/PNAS.1516401112
P407
P577
2015-11-09T00:00:00Z