A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors.
about
Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.A two-step, two-signal model for the primary activation of precursor helper T cellsReprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies.In vitro maturation of immature thymocytes into immunocompetent T cells in the absence of direct thymic influence.In vitro generation of antigen-specific helper T cells that collaborate with cytotoxic T-cell precursors.Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokinesA T helper cell for anti-viral cytotoxic T-cell responses.Quantitative studies on the precursors of cytotoxic lymphocytes. VI. Second signal requirements of specifically activated precursors isolated 12 h after stimulation.Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.Multiple pathways of T-T interaction in the generation of cytotoxic T lymphocytes to alloantigens.On the T cell hyperreactivity of NZB mice against H-2-identical cells. Evidence for primary response characteristics and an increased helper potentialEffect of helper T cells on the primary in vitro production of delayed-type hypersensitivity to influenza virus.Analysis of H-2 determinants recognized during the induction of H-Y-immune cytotoxic T cells by monoclonal antibodies in vitro.Helper activity is required for the in vivo generation of cytotoxic T lymphocytesT cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants.Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responsesCellular interactions in the generation of cytolytic T lymphocyte responses: role of Ia-positive splenic adherent cells in presentation in H-2 antigen.Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens.Transgenic models of tolerance and autoimmunity.Soluble antigen-specific helper molecules active in the induction of cytotoxic T lymphocytes.Alloreactivity, the development of the T cell repertoire and the understanding of T cell function.Mechanisms of idiotype suppression. I. In vitro generation of idiotype-specific suppressor T cells by anti-idiotype antibodies and specific antigenA specific helper factor which enhances the cytotoxic response to a syngeneic tumour.A suggested mechanism for T lymphocyte activation: implications on the acquisition of functional reactivities.The role of T cell growth stimulating factors in T cell triggering.Cellular origins and targets of costimulator (IL2).T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell derived helper factor (Interleukin 2) as a probe to analyze CTL responsiveness and thymic maturation of CTL progenitors.Interleukin 2: a class of T cell growth factors.Helper T cells are required for the polyclonal stimulation of cytotoxic T cells by concanavalin A.Ontogeny of cell-mediated immunity. I. Early development of alloantigen-specific cytotoxic T-cell precursors in postnatal mice.Relationships among differentiated T-cell subpopulations. III. Radioresistance of delayed hypersensitivity to heterologous erythrocytes.Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus.T-T cell interactions during in vitro cytotoxic T lymphocyte responses. V. Precursor frequencies and specificity of alloreactive helper T cells.Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of "mature" thymocytes as analyzed by monoclonal antibodies and flow microVaccinia-interleukin 2 recombinant virus or exogenous interleukin 2 does not alter the magnitude or immune response gene defects of the cytotoxic T-cell response to vaccinia virus in vivo.Increasing the foreignness of an antigen, by coupling a second and foreign antigen to it, increases the T helper type 2 component of the immune response to the first antigen.Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC.Epitope affinity for MHC class I determines helper requirement for CTL priming.
P2860
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P2860
A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors.
description
1977 nî lūn-bûn
@nan
1977年の論文
@ja
1977年学术文章
@wuu
1977年学术文章
@zh-cn
1977年学术文章
@zh-hans
1977年学术文章
@zh-my
1977年学术文章
@zh-sg
1977年學術文章
@yue
1977年學術文章
@zh
1977年學術文章
@zh-hant
name
A requirement for antigen-spec ...... lls from thymocyte precursors.
@ast
A requirement for antigen-spec ...... lls from thymocyte precursors.
@en
type
label
A requirement for antigen-spec ...... lls from thymocyte precursors.
@ast
A requirement for antigen-spec ...... lls from thymocyte precursors.
@en
prefLabel
A requirement for antigen-spec ...... lls from thymocyte precursors.
@ast
A requirement for antigen-spec ...... lls from thymocyte precursors.
@en
P2860
P356
P1476
A requirement for antigen-spec ...... lls from thymocyte precursors.
@en
P2093
Pilarski LM
P2860
P304
P356
10.1084/JEM.145.3.709
P407
P577
1977-03-01T00:00:00Z