NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.
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Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?Autophagy proteins control goblet cell function by potentiating reactive oxygen species productionNew insights into the roles of NADPH oxidases in sexual development and ascospore germination in Sordaria macrospora.Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesityUncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets.Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activityNOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress.Opportunity "nox": a novel approach to preventing endothelial dysfunction in the context of insulin resistance.The Amplifying Pathway of the β-Cell Contributes to Diet-induced ObesityLoss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies.Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.Iron: the hard player in diabetes pathophysiology.The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia.Oxidized phagosomal NOX2 complex is replenished from lysosomes.NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction.IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death.Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity.Crucial roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice.Bach1 deficiency protects pancreatic β-cells from oxidative stress injury.Inhibition of NADPH oxidase-1 preserves beta cell function.Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway.Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion.The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic β-cells.Hyperspectral imaging for simultaneous measurements of two FRET biosensors in pancreatic β-cells.Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.Exendin-4 alleviates angiotensin II-induced senescence in vascular smooth muscle cells by inhibiting Rac1 activation via a cAMP/PKA-dependent pathway.
P2860
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P2860
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
NADPH oxidase NOX2 defines a n ...... gulation of insulin secretion.
@ast
NADPH oxidase NOX2 defines a n ...... gulation of insulin secretion.
@en
type
label
NADPH oxidase NOX2 defines a n ...... gulation of insulin secretion.
@ast
NADPH oxidase NOX2 defines a n ...... gulation of insulin secretion.
@en
prefLabel
NADPH oxidase NOX2 defines a n ...... gulation of insulin secretion.
@ast
NADPH oxidase NOX2 defines a n ...... gulation of insulin secretion.
@en
P2093
P2860
P356
P1433
P1476
NADPH oxidase NOX2 defines a n ...... egulation of insulin secretion
@en
P2093
Christine Deffert-Delbouille
Karl-Heinz Krause
Thierry Brun
Xiao-Juan Ma
Youssef Daali
Zahia Mahiout
P2860
P304
P356
10.2337/DB12-0009
P407
P577
2012-08-28T00:00:00Z