Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials
about
Novel adjunctive therapies for the treatment of tuberculosisA medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosisLearning from the past for TB drug discovery in the futureIdentification of a small molecule with activity against drug-resistant and persistent tuberculosisTB drug development: immunology at the tableNew insights into TB physiology suggest untapped therapeutic opportunitiesEnhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian modelsLooking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosisTackling tuberculosis: Insights from an international TB Summit in LondonTB Mobile: a mobile app for anti-tuberculosis molecules with known targetsNew tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeuticsRifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery.Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay.Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation modelCombining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery.Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.Mycobacterium tuberculosis metabolismE1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosisPersistent bacterial infections, antibiotic tolerance, and the oxidative stress response.Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis.Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureus.Host-directed therapeutics for tuberculosis: can we harness the host?The future for early-stage tuberculosis drug discoveryImproving the tuberculosis drug development pipeline.Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.Kunkel Lecture: Fundamental immunodeficiency and its correction.Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review.Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis.Recognizing drug targets using evolutionary information: implications for repurposing FDA-approved drugs against Mycobacterium tuberculosis H37Rv.Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria.Microbiology. Eliminating malaria.Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis.Hit Generation in TB Drug Discovery: From Genome to Granuloma.Susceptibilities of MDR Mycobacterium tuberculosis isolates to unconventional drugs compared with their reported pharmacokinetic/pharmacodynamic parameters.Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
P2860
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P2860
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Nonsteroidal anti-inflammatory ...... s and exogenous antimicrobials
@ast
Nonsteroidal anti-inflammatory ...... s and exogenous antimicrobials
@en
type
label
Nonsteroidal anti-inflammatory ...... s and exogenous antimicrobials
@ast
Nonsteroidal anti-inflammatory ...... s and exogenous antimicrobials
@en
prefLabel
Nonsteroidal anti-inflammatory ...... s and exogenous antimicrobials
@ast
Nonsteroidal anti-inflammatory ...... s and exogenous antimicrobials
@en
P2093
P2860
P921
P356
P1476
Nonsteroidal anti-inflammatory ...... s and exogenous antimicrobials
@en
P2093
Aditya Venugopal
Amy Cunningham-Bussel
Carl F Nathan
Crystal Darby
Eric L Nuermberger
Haiteng Deng
J Fraser Glickman
Joseph Fernandez
Julia Roberts
P2860
P304
16004-16011
P356
10.1073/PNAS.1214188109
P407
P577
2012-09-10T00:00:00Z