Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus
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Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killingMolecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigensSubunit structure of cell surface proteins: disulfide bonding in antigen receptors, Ly-2/3 antigens, and transferrin receptors of murine T and B lymphocytesFormal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2.Isolation and partial characterization of concanavalin A receptors on cloned cytotoxic T lymphocytesMouse Lyt-2 antigen: evidence for two heterodimers with a common subunit.Selective blockade of human natural killer cells by a monoclonal antibody.Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and manLyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis.Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in manPossible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.A clone-specific monoclonal antibody that inhibits cytolysis of a cytolytic T cell clone.Spontaneous release of the Leu-2 (T8) molecule from human T cellsEffect of in vivo administration of Lyt antibodies. Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejectionAbsence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.Inhibition of MHC class II-restricted T cell response by Lyt-2 alloantigen.Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.Alloantigen-induced T-cell proliferation: Lyt phenotype of responding cells and blocking of proliferation by Lyt antisera.Trojan horse lymphocytes: a vesicular stomatitis virus-specific T-cell clone lyses target cells by carrying virus.Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.Distinct functions of CD8(CD4) are utilized at different stages of T-lymphocyte differentiation.Acquisition of cytotoxic T lymphocyte-specific carbohydrate differentiation antigens.CD4 expression and function in HLA class II-specific T cells.Established murine cytolytic T-cell lines as tools for a somatic cell genetic analysis of T-cell functions.Cloned T lymphocytes and monoclonal antibodies as probes for cell surface molecules active in T cell-mediated cytolysis.LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.Lymphoid cell surface interaction structures detected using cytolysis-inhibiting monoclonal antibodies.Requirement for the involvement of clonally distributed receptors in the activation of cytotoxic T lymphocytes.Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.Molecular interactions in T-cell-mediated cytotoxicity.Effects of anti-Lyt antibodies on T-cell functions.T cell subsets and the recognition of MHC class.The mechanism of CTL-mediated killing: monoclonal antibody analysis of the roles of killer and target-cell membrane proteins.
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P2860
Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年学术文章
@wuu
1979年学术文章
@zh-cn
1979年学术文章
@zh-hans
1979年学术文章
@zh-my
1979年学术文章
@zh-sg
1979年學術文章
@yue
1979年學術文章
@zh
1979年學術文章
@zh-hant
name
Mouse alloantibodies capable o ...... antibodies and the Lyt-2 locus
@ast
Mouse alloantibodies capable o ...... antibodies and the Lyt-2 locus
@en
type
label
Mouse alloantibodies capable o ...... antibodies and the Lyt-2 locus
@ast
Mouse alloantibodies capable o ...... antibodies and the Lyt-2 locus
@en
prefLabel
Mouse alloantibodies capable o ...... antibodies and the Lyt-2 locus
@ast
Mouse alloantibodies capable o ...... antibodies and the Lyt-2 locus
@en
P2860
P356
P1476
Mouse alloantibodies capable o ...... antibodies and the Lyt-2 locus
@en
P2093
P2860
P304
P356
10.1084/JEM.150.3.432
P407
P577
1979-09-01T00:00:00Z