The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.
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Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb bindingMolecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34Localization of the binding site for the monocyte immunoglobulin (Ig) A-Fc receptor (CD89) to the domain boundary between Calpha2 and Calpha3 in human IgA1Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and LynHuman IgG4: a structural perspectiveThe structure of a human type III Fcgamma receptor in complex with FcStructural characterization of a human Fc fragment engineered for lack of effector functionsStructure of an isolated unglycosylated antibody CH2 domainStructural Determinants of Unique Properties of Human IgG4-FcCrystal structure of deglycosylated human IgG4-FcChannel catfish soluble FcmuR binds conserved linear epitopes present on Cmu3 and Cmu4Advances in Antibody DesignSolid-phase synthesis and cyclization of a large branched peptide from IgG Fc with affinity for Fc gammaRI.Complement therapy in atypical haemolytic uraemic syndrome (aHUS).Improved biodistribution, tumor targeting, and reduced immunogenicity in mice with a gamma 4 variant of Campath-1H.Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1Autoregulatory circuits in myeloma. Tumor cell cytotoxicity mediated by soluble CD16.IgG subclasses and allotypes: from structure to effector functions.Transferrin-antibody fusion proteins are effective in brain targetingGenetically-engineered antibodies: tools for the study of diverse properties of the antibody molecule.Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3).A noncytolytic antibody-like extendin-4-IgG4 fusion protein as a long-acting potential anti-diabetic agent.Development of sandwich dot-ELISA for specific detection of Ochratoxin A and its application on to contaminated cereal grains originating from IndiaHuman IgG2 antibodies display disulfide-mediated structural isoforms.Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infection.IgG4-related disease: case report and literature review.Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention.Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responsesIgG4 can induce an M2-like phenotype in human monocyte-derived macrophages through FcγRI.The contribution of allergen-specific IgG to the development of th2-mediated airway inflammationStructural features of human immunoglobulin G that determine isotype-specific differences in complement activation.Effect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1.The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.Development of a specific system for targeting protein to metallophilic macrophages.Homogeneous immunoconjugates for boron neutron-capture therapy: design, synthesis, and preliminary characterization.Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein.Rationale for anti-CD200 immunotherapy in B-CLL and other hematologic malignancies: new concepts in blocking immune suppression.Association between IgG4 Autoantibody and Complement Abnormalities in Systemic Lupus Erythematosus.Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates.Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.
P2860
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P2860
The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
The binding affinity of human ...... modulated by the hinge region.
@ast
The binding affinity of human ...... modulated by the hinge region.
@en
type
label
The binding affinity of human ...... modulated by the hinge region.
@ast
The binding affinity of human ...... modulated by the hinge region.
@en
prefLabel
The binding affinity of human ...... modulated by the hinge region.
@ast
The binding affinity of human ...... modulated by the hinge region.
@en
P2860
P356
P1476
The binding affinity of human ...... modulated by the hinge region.
@en
P2093
S L Morrison
S M Canfield
P2860
P304
P356
10.1084/JEM.173.6.1483
P407
P577
1991-06-01T00:00:00Z