The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]
about
Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte developmentLigand-engaged TCR is triggered by Lck not associated with CD8 coreceptorRequirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selectionLck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitionsDecreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytesThe kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation.The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.Lck plays a critical role in Ca(2+) mobilization and CD28 costimulation in mature primary T cells.
P2860
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P2860
The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]
description
1993 nî lūn-bûn
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1993年の論文
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1993年学术文章
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1993年学术文章
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1993年学术文章
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1993年学术文章
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1993年学术文章
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1993年學術文章
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1993年學術文章
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1993年學術文章
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name
The protein tyrosine kinase p5 ...... nd CD8 coreceptors [corrected]
@ast
The protein tyrosine kinase p5 ...... nd CD8 coreceptors [corrected]
@en
type
label
The protein tyrosine kinase p5 ...... nd CD8 coreceptors [corrected]
@ast
The protein tyrosine kinase p5 ...... nd CD8 coreceptors [corrected]
@en
prefLabel
The protein tyrosine kinase p5 ...... nd CD8 coreceptors [corrected]
@ast
The protein tyrosine kinase p5 ...... nd CD8 coreceptors [corrected]
@en
P2093
P2860
P356
P1476
The protein tyrosine kinase p5 ...... nd CD8 coreceptors [corrected]
@en
P2093
K A Forbush
K M Abraham
R M Perlmutter
S J Anderson
P2860
P304
P356
10.1084/JEM.178.1.245
P407
P577
1993-07-01T00:00:00Z