Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.
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9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activityMolecular characterization of the variable domains of an alphaIIbbeta3-specific immunoglobulin M kappa platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between alphaII9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles.The NOD/SCID chimeric mouse model of human B cell development: studies on the VH4 family immunoglobulin repertoire and implications for SLE.Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Specific Human Monoclonal AntibodiesRegulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance.Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.Virginia Pascual, MD: a conversation with the editorClonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosusB cells and immunological tolerance.Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.Restricted, canonical, stereotyped and convergent immunoglobulin responses.Differential usage of an autoantibody-associated VH gene, VH4-21, by human B-cell tumors.Recognition of auto- and exoantigens by V4-34 gene encoded antibodies.Idiotype manipulation for autoimmune diseases: where are we going?Molecular characterization of monoclonal IgM derived from human B cell lines expressing the 4C9 rheumatoid factor associated idiotype.The cross-reactive idiotopes recognized by the monoclonal antibodies 9G4 and LC1 are located in framework region 1 of two non-overlapping subsets of human VH4 family encoded antibodies.Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.Staphylococcal protein A binding to VH3 encoded immunoglobulins.B cell superantigens: potential modifiers of the normal human B cell repertoire.Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment.Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysisStructural analysis of VH4-21 encoded human IgM allo- and autoantibodies against red blood cells.Anti-idiotypic antibodies induced by genetic immunisation are directed exclusively against combined V(L)/V(H) determinants.Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection.Novel diagnostic and therapeutic strategies with genetically engineered human antibodies.Expression of Y7 cross-reactive idiotope on human IgM molecules.
P2860
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P2860
Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Molecular characterization of ...... izing the VH4-21 gene segment.
@ast
Molecular characterization of ...... izing the VH4-21 gene segment.
@en
type
label
Molecular characterization of ...... izing the VH4-21 gene segment.
@ast
Molecular characterization of ...... izing the VH4-21 gene segment.
@en
prefLabel
Molecular characterization of ...... izing the VH4-21 gene segment.
@ast
Molecular characterization of ...... izing the VH4-21 gene segment.
@en
P2093
P2860
P356
P1476
Molecular characterization of ...... izing the VH4-21 gene segment.
@en
P2093
F K Stevenson
K N Potter
M Spellerberg
R C Williams
P2860
P304
P356
10.1084/JEM.178.4.1419
P407
P577
1993-10-01T00:00:00Z