CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. - Wikidata - wikimedia - TriplyDB

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

http://www.wikidata.org/entity/Q36362675

about

CTLA-4 ligation blocks CD28-dependent T cell activation Cell fate decision: T-helper 1 and 2 subsets in immune responses.A cellular calculus for signal integration by T cells Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy.Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease Activation of the immune system in cancer patients.Biotherapeutic targets for the treatment of allergic airway disease.MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.CTLA-4 regulates cell cycle progression during a primary immune response.CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion.Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on cell division and Th1/Th2 cytokine production Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production.IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites.CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease Cytokine transcriptional events during helper T cell subset differentiation.Limited role of CD28-mediated signals in T helper subset differentiation Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2 In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.IL-7- and IL-15-mediated TCR sensitization enables T cell responses to self-antigens.Inflammatory bowel disease: past, present, and future Targeting the B7 family of co-stimulatory molecules: successes and challenges.Negative regulation of Th17 responses Interleukin 2 plays a central role in Th2 differentiation.Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.Targeting co-stimulatory pathways in gene therapy Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.Potential targeting of B7-H4 for the treatment of cancer.Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells.Costimulation in tolerance and autoimmunity.CD28: a signalling perspective.The complexities of T-cell co-stimulation: CD28 and beyond.Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation.

P2860

Q24678229-FFB4CC10-7B72-431E-BE82-54995023E752 Q24806926-938C3EAE-CAFE-4383-8D30-D69D16178BA2 Q28145380-7FADAA82-0EB7-40B0-A9E4-FE81D48A690C Q28267489-AFBB9740-9FE3-4EC2-9ED0-556110FA2CE0 Q33753720-240C4C83-3AED-42AD-8D85-03B30CD5DDDD Q33785953-AF95E240-AD86-45AE-A111-B3783D48B933 Q33803922-72BE1D21-7D63-4A10-9B6D-297F11F1C289 Q34058685-2F78C635-5790-4685-9312-D354390CF171 Q34106637-F06D862C-D42F-4A49-98AA-120E1E17258F Q34168242-C9C96176-B521-42C6-9BFD-FED27C9072B4 Q34520577-BC5E1C85-A3E0-484F-BCA6-C878B0492971 Q34985437-D0CD7649-1308-43F6-B3AF-0C885D6A03A9 Q35157436-BB0227EE-9953-4E57-9A9E-71D191799E3C Q35765938-826D3893-BB4E-442B-963C-C583EDBA81DA Q35839888-090DA069-03A0-4605-BAAB-A649A8FBB63F Q35848067-BAB360B9-1F9F-4C30-A3FA-E3970D02C195 Q35940715-7C5B2B47-6B87-4D4F-BCDD-9EAEE6C9AAB6 Q35995946-E994F803-93AB-47B2-A846-23D3230A8503 Q36363477-E2EAC247-6739-4916-AE9B-2BDE6273D085 Q36363984-3DE94CAC-890A-438B-9810-FEC407330305 Q36364843-E8882150-44EC-43C9-BF90-690204C65EF5 Q36365191-9539AEA7-1307-4EED-AA89-AE0ABE7E3BD2 Q36367214-CE81586A-D49D-4F01-996E-65476ECB4ADD Q36367295-60AB0C9A-EF70-4BDC-83FA-75DD302D7AEB Q36367671-DD82EA91-7562-4F99-9CE4-AACDC7480FF6 Q36401253-4787B287-2630-4956-936A-E68B7AE12C02 Q36616642-6A047B33-5D5D-48E6-9D9B-B00D9E1E89EA Q36745440-97780B07-BA49-45A5-97C7-009FD300AE1A Q36841260-CACC8762-C390-4509-948D-F484D14BEF5F Q37067780-9402BF17-3B30-43FD-86C3-DC595074AAE9 Q37095134-3F3668C7-147C-4341-9A37-9F219517233F Q37374258-E70898E7-D22D-427F-BE17-A5AD80491301 Q37951935-F9221A5D-36A9-4B13-B5D0-10D03128A093 Q38331020-6479EBA8-FCCB-451C-B5C8-EE7F2A1F25C5 Q38930119-87A54BD6-A0C4-4406-B9DA-6EBAFBDBA7DF Q40020684-52C7FF34-EFFC-4471-8024-4DAF242C584A Q41098076-BBB85D61-031B-4893-93AD-4C736F9DED46 Q41113501-1762D7C8-E826-4165-B6DB-D4E329370BAF Q41332130-9DE62DC0-55CD-451E-B56D-3F36CC88338D Q41643177-49095CDA-BCAB-499C-9517-9D4DC7EB33F2

P2860

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

http://www.wikidata.org/entity/Q36362675

description

1994 nî lūn-bûn

@nan

1994年の論文

@ja

1994年学术文章

@wuu

1994年学术文章

@zh-cn

1994年学术文章

@zh-hans

1994年学术文章

@zh-my

1994年学术文章

@zh-sg

1994年學術文章

@yue

1994年學術文章

@zh

1994年學術文章

@zh-hant

name

CD28-mediated costimulation of ...... d interferon gamma production.

@ast

CD28-mediated costimulation of ...... d interferon gamma production.

@en

type

label

CD28-mediated costimulation of ...... d interferon gamma production.

@ast

CD28-mediated costimulation of ...... d interferon gamma production.

@en

prefLabel

CD28-mediated costimulation of ...... d interferon gamma production.

@ast

CD28-mediated costimulation of ...... d interferon gamma production.

@en

P1433

Q36362675-44720381-46FE-45E7-BA15-F67B79A72472

P1476

Q36362675-4429DE02-B8A8-4CA2-A880-0DD9D6AAC764

P2093

Q36362675-55D6B95D-75F4-4213-AD55-D4C329D63D3A

Q36362675-CEFC0589-06C5-4B5E-A8A2-AEE3C1772E1E

Q36362675-F58199B9-6446-43C6-9CD6-587C653DA83A

Q36362675-FD94753F-2862-4861-9256-C03A8D7437E1

P2860

Q36362675-00D778F2-BA83-43EC-8822-1634F79F4E63

Q36362675-0E331750-1323-49AE-89D9-721A3E26FEAE

Q36362675-104D2AD7-391F-4E7C-B8E0-281BAFA9D441

Q36362675-1421E785-AB2F-4E2D-94FD-659205AAA78A

Q36362675-1A885E06-6D93-4783-9319-3CA8B0D7B3BD

Q36362675-3C355269-D426-4027-8768-D5850BFDB495

Q36362675-3E2D7B67-CF42-471C-8949-80BA623812FC

Q36362675-452818F9-AD85-4E1D-BE2A-AA75932ADE3D

Q36362675-4ADDF136-E9D9-4245-AF4A-C511904DCABA

Q36362675-679977FA-5F72-4870-A6BF-F6620E31C796

P304

Q36362675-4802CDD6-F3F8-47DB-B76B-AE76143D3E43

P31

Q36362675-53C543DD-B615-485D-9D81-CCD342CF69E3

P356

Q36362675-F2F2C741-2C1B-4FF7-A058-59AD177BF623

P407

Q36362675-EE79A6A7-A516-4B8D-803D-465DE70E9A30

P433

Q36362675-72F97BB9-A7A6-45D2-BE7B-98B278CC738F

P478

Q36362675-42581CCF-EB18-47EB-A25B-80D0CEE0B75B

P577

Q36362675-2CC9C052-F77C-4315-8866-65BB152FABE4

P5875

Q36362675-DDAE3DB7-9FFA-4690-B603-702F725DDE5A

P698

Q36362675-A1F365A5-8377-43AC-BC75-720F6C504A43

P932

Q36362675-5670549B-1471-4620-875C-DA5480194A19

P356

P1433

Journal of Experimental Medicine

P1476

CD28-mediated costimulation of ...... d interferon gamma production.

@en

P2093

Germain RN

http://www.w3.org/2001/XMLSchema#string

Linsley PS

http://www.w3.org/2001/XMLSchema#string

Paul WE

http://www.w3.org/2001/XMLSchema#string

Seder RA

http://www.w3.org/2001/XMLSchema#string

P2860

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.

CTLA-4 is a second receptor for the B cell activation antigen B7

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

P304

299-304

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1084/JEM.179.1.299

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

179

http://www.w3.org/2001/XMLSchema#string

P577

1994-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

238253939

http://www.w3.org/2001/XMLSchema#string

P698

8270872

http://www.w3.org/2001/XMLSchema#string

P932

2191346

http://www.w3.org/2001/XMLSchema#string