Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
about
Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpainITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytesCell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand RecognitionStable interactions and sustained TCR signaling characterize thymocyte-thymocyte interactions that support negative selectionExpression of the Bcl-2 family member A1 is developmentally regulated in T cellsRhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte developmentEnhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigenSeveral different cell surface molecules control negative selection of medullary thymocytesComparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice.Regulation of T cell development and activation by creatine kinase B.Apoptosis in human autoimmune diseases.When immunization leads to autoimmunity: chronic inflammation as a result of thymic and mucosal dysregulation in IL-2 knock-out mice.T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.T-cell signaling regulated by the Tec family kinase, Itk.The role of the thymus in tolerance.Organ-specific autoimmune disease: a deficiency of tolerogenic stimulationNegative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramersCostimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes.ORAI1 deficiency impairs activated T cell death and enhances T cell survivalGSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulationCross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell deathHistone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytesClonal deletion and the fate of autoreactive thymocytes that survive negative selection.Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection.The B7/CD28 costimulatory family in autoimmunity.Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, andT cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.Human T lymphocyte virus 1 from a leukemogenic cell line mediates in vivo and in vitro lymphocyte apoptosisAn essential role for gp39, the ligand for CD40, in thymic selection.Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic miceInhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cellsRescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2Tec family kinases modulate thresholds for thymocyte development and selection.Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells.Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes.Quantitative impact of thymic clonal deletion on the T cell repertoire.Induction of the early growth response (Egr) family of transcription factors during thymic selection.Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes
P2860
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P2860
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
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1994年學術文章
@zh-hant
name
Negative selection of CD4+CD8+ ...... l that can be provided by CD28
@ast
Negative selection of CD4+CD8+ ...... l that can be provided by CD28
@en
type
label
Negative selection of CD4+CD8+ ...... l that can be provided by CD28
@ast
Negative selection of CD4+CD8+ ...... l that can be provided by CD28
@en
prefLabel
Negative selection of CD4+CD8+ ...... l that can be provided by CD28
@ast
Negative selection of CD4+CD8+ ...... l that can be provided by CD28
@en
P2093
P2860
P356
P1476
Negative selection of CD4+CD8+ ...... l that can be provided by CD28
@en
P2093
P2860
P304
P356
10.1084/JEM.179.2.709
P407
P577
1994-02-01T00:00:00Z