Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo
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Abatacept and reduced immune response to pandemic 2009 influenza A/H1N1 vaccination in patients with rheumatoid arthritis.The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines.The role of B7 costimulation in T-cell immunity.CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris.Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.Antiviral immune responses in CTLA4 transgenic mice.CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasiteA pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cellsThe T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response.T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.Limited role of CD28-mediated signals in T helper subset differentiationConstitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice.Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes.CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen.Translating costimulation blockade to the clinic: lessons learned from three pathways.Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responsesStructural immunology of costimualtory and coinhibitory molecules.Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma.Costimulation in tolerance and autoimmunity.Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.CD80, CD86 and CD40 provide accessory signals in a multiple-step T-cell activation model.The changing preference of T and B cells for partners as T-dependent antibody responses develop.Regulation of T and B cell responses by modulating interactions between CD28/CTLA4 and their ligands, CD80 and CD86.Immunosenescence and germinal center reaction.CD80 costimulation is essential for the induction of airway eosinophiliaB cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cellsCompromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice.Th2 cells and cytokine networks in allergic inflammation of the lung.Fully human anti-BAFF inhibitory monoclonal antibody tabalumab does not adversely affect T-dependent antibody responses in cynomolgus monkey (Macaca fasicularis): A summary of three pre-clinical immunotoxicology evaluations.
P2860
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P2860
Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Mice transgenic for a soluble ...... ve antibody production in vivo
@ast
Mice transgenic for a soluble ...... ve antibody production in vivo
@en
type
label
Mice transgenic for a soluble ...... ve antibody production in vivo
@ast
Mice transgenic for a soluble ...... ve antibody production in vivo
@en
prefLabel
Mice transgenic for a soluble ...... ve antibody production in vivo
@ast
Mice transgenic for a soluble ...... ve antibody production in vivo
@en
P2093
P2860
P356
P1476
Mice transgenic for a soluble ...... ve antibody production in vivo
@en
P2093
P2860
P304
P356
10.1084/JEM.179.3.809
P407
P577
1994-03-01T00:00:00Z