Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein
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Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disordersS-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's diseaseInflammation and Alzheimer's diseaseDeletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's diseaseSerotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretionTranssynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor proteinA dinucleotide deletion in amyloid precursor protein (APP) mRNA associated with sporadic Alzheimer's disease results in efficient secretion of truncated APP isoforms from neuroblastoma cell cultures.Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic miceThe amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesSelective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathyTOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine.Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline.Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain.HIV-gp120 and physical dependence to buprenorphineImpaired neurogenesis by HIV-1-Gp120 is rescued by genetic deletion of fatty acid amide hydrolase enzyme.Prevalence of Alzheimer plaques in AIDS.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Neurotrophic and neuroprotective effects of hAPP in transgenic mice.Molecular and pathologic insights from latent HIV-1 infection in the human brainNeuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity.Mitogen-activated protein kinase p38 in HIV infection and associated brain injury.Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injuryDysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis.The cannabinoid CB₂ receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis.The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathwayEffects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy.Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat.Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease.Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis.Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research.Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model.Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation.Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120."APP"reciating the complexity of HIV-induced neurodegenerative diseases
P2860
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P2860
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Protection against HIV-1 gp120 ...... uman amyloid precursor protein
@ast
Protection against HIV-1 gp120 ...... uman amyloid precursor protein
@en
type
label
Protection against HIV-1 gp120 ...... uman amyloid precursor protein
@ast
Protection against HIV-1 gp120 ...... uman amyloid precursor protein
@en
prefLabel
Protection against HIV-1 gp120 ...... uman amyloid precursor protein
@ast
Protection against HIV-1 gp120 ...... uman amyloid precursor protein
@en
P2093
P2860
P356
P1476
Protection against HIV-1 gp120 ...... uman amyloid precursor protein
@en
P2093
C R Abraham
E M Rockenstein
S M Toggas
P2860
P304
P356
10.1084/JEM.181.4.1551
P407
P577
1995-04-01T00:00:00Z