Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
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The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice.Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasisHigh quality long-term CD4+ and CD8+ effector memory populations stimulated by DNA-LACK/MVA-LACK regimen in Leishmania major BALB/c model of infection.A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 2-model applications.DM determines the cryptic and immunodominant fate of T cell epitopes.Leishmania major LACK antigen is required for efficient vertebrate parasitization.Altered peptide ligands can modify the Th2 T cell response to the immunodominant 161-175 peptide of LACK (Leishmania homolog for the receptor of activated C kinase).A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis.The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c miceIncreased production of interferon-gamma by Leishmania homologue of the mammalian receptor for activated C kinase-reactive CD4+ T cells among human blood mononuclear cells: an early marker of exposure to Leishmania?Combination of In Silico Methods in the Search for Potential CD4(+) and CD8(+) T Cell Epitopes in the Proteome of Leishmania braziliensis.T-cell responses to immunodominant LACK antigen do not play a critical role in determining susceptibility of BALB/c mice to Leishmania mexicana.Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis.LACK-specific CD4(+) T cells that induce gamma interferon production in patients with localized cutaneous leishmaniasis during an early stage of infection.Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells.Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation.
P2860
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P2860
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
description
1999 nî lūn-bûn
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1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
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1999年學術文章
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name
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
@ast
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
@en
type
label
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
@ast
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
@en
prefLabel
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
@ast
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
@en
P2093
P2860
P356
P1476
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
@en
P2093
D J Fowell
N Glaichenhaus
R M Locksley
S Southwood
P2860
P304
P356
10.1084/JEM.189.7.1111
P407
P577
1999-04-01T00:00:00Z