The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
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A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapyBAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrestPolyamine depletion delays apoptosis of rat intestinal epithelial cellsProtection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase.Differential regulation of cell cycle-related proteins by CD95 engagement in thymocytes and T cell leukemic cell line, Jurkat.Ectopic expression of cyclin D1 amplifies a retinoic acid-induced mitochondrial death pathway in breast cancer cells.Coupling of the cell cycle and apoptotic machineries in developing T cells.Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis.Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells.Adverse effects of simulated hyper- and hypo-phosphatemia on endothelial cell function and viability.In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell.Bcl-2 in cell-cycle regulation of hematopoietic cells by transforming growth factor-beta1.Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells.Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis.Origin licensing and programmed cell death: a hypothesis.The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - RoscovitineHematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunityCaspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis.Caspase-dependent Cdk activity is a requisite effector of apoptotic death events.Cytoplasmic initiation of cisplatin cytotoxicity.Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage.Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury.Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cellsProteomic insights into cardiac cell death and survival.Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation.Transcriptional modulation of apoptosis regulators by roscovitine and related compounds.Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.Identification of the functional domain of p21(WAF1/CIP1) that protects cells from cisplatin cytotoxicity.Inhibition of glucocorticoid-induced apoptosis in 697 pre-B lymphocytes by the mineralocorticoid receptor N-terminal domain.Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells.Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle.A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells.Inhibition of ultraviolet B (UVB) induced apoptosis in A431 cells by mimosine is not dependent on cell cycle arrest.Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation and disease.MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer.Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer.
P2860
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P2860
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
@ast
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
@en
type
label
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
@ast
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
@en
prefLabel
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
@ast
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
@en
P2093
P2860
P356
P1476
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
@en
P2093
Kozieradzki I
Penninger JM
P2860
P304
P356
10.1084/JEM.189.6.957
P407
P577
1999-03-01T00:00:00Z