Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.
about
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionUpregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.The MHC class II cofactor HLA-DM interacts with Ig in B cells.H2-O, a MHC class II-like protein, sets a threshold for B-cell entry into germinal centers.The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.Right place, right time, right peptide: DO keeps DM focused.pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.Ubiquitination of HLA-DO by MARCH family E3 ligases.MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes.Accelerated turnover of MHC class II molecules in nonobese diabetic mice is developmentally and environmentally regulated in vivo and dispensable for autoimmunity.HLA-DO and Its Role in MHC Class II Antigen Presentation.Inhibition of HLA-DM Mediated MHC Class II Peptide Loading by HLA-DO Promotes Self ToleranceTLR agonists downregulate H2-O in CD8alpha- dendritic cells.The Other Function: Class II-Restricted Antigen Presentation by B Cells.Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient.Sibling rivalry: competition between MHC class II family members inhibits immunity.
P2860
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P2860
Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.
description
2002 nî lūn-bûn
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2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
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@zh
2002年學術文章
@zh-hant
name
Regulated expression of human ...... phases of B cell development.
@ast
Regulated expression of human ...... phases of B cell development.
@en
type
label
Regulated expression of human ...... phases of B cell development.
@ast
Regulated expression of human ...... phases of B cell development.
@en
prefLabel
Regulated expression of human ...... phases of B cell development.
@ast
Regulated expression of human ...... phases of B cell development.
@en
P2093
P2860
P356
P1476
Regulated expression of human ...... phases of B cell development.
@en
P2093
Dominique A Weber
Lars Karlsson
Oskar Laur
Peter E Jensen
Robert A Bray
Shiyong Li
Taku Kambayashi
Xinjian Chen
P2860
P304
P356
10.1084/JEM.20012066
P407
P577
2002-04-01T00:00:00Z