The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes
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Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those withoutResequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus erythematosus cases.Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAMComplement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3Advances in lupus genetics and epigeneticsPhagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cellsRare variants at 16p11.2 are associated with common variable immunodeficiencySerological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium.CD11c/CD18 Dominates Adhesion of Human Monocytes, Macrophages and Dendritic Cells over CD11b/CD18Genetics of Lupus Nephritis: Clinical Implications.Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.Genetics of SLE: functional relevance for monocytes/macrophages in diseaseComplement receptor 3 influences toll-like receptor 7/8-dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins.Complement Opsonization Promotes Herpes Simplex Virus 2 Infection of Human Dendritic Cells.The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling.CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.Gene-function studies in systemic lupus erythematosus.The CD11b-integrin (ITGAM) and systemic lupus erythematosus.The complement system in systemic lupus erythematosus: an update.Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus.Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis.Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis.The many faces of Mac-1 in autoimmune disease.Loading of nuclear autoantigens prototypically recognized by systemic lupus erythematosus sera into late apoptotic vesicles requires intact microtubules and myosin light chain kinase activity.Non-canonical autophagy LAPs lupus.Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.The Systemic Lupus Erythematosus-Associated Single Nucleotide Polymorphism rs1143678 in Integrin αM Cytoplasmic Tail Generates a 14-3-3ζ Binding Site That Is Proinflammatory.Association of the CD11b rs1143679 polymorphism with systemic lupus erythematosus in the Han Chinese population.CD11b Activity Modulates Pathogenesis of Lupus Nephritis.Genetics of human lupus nephritis.
P2860
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P2860
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes
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2012 nî lūn-bûn
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2012年学术文章
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The rs1143679 (R77H) lupus ass ...... d functions in human monocytes
@ast
The rs1143679 (R77H) lupus ass ...... d functions in human monocytes
@en
type
label
The rs1143679 (R77H) lupus ass ...... d functions in human monocytes
@ast
The rs1143679 (R77H) lupus ass ...... d functions in human monocytes
@en
prefLabel
The rs1143679 (R77H) lupus ass ...... d functions in human monocytes
@ast
The rs1143679 (R77H) lupus ass ...... d functions in human monocytes
@en
P2093
P2860
P50
P1476
The rs1143679 (R77H) lupus ass ...... d functions in human monocytes
@en
P2093
Amy L Roberts
Barbara G Fürnrohr
George Tzircotis
Tim D Spector
P2860
P304
P356
10.1136/ANNRHEUMDIS-2012-201390
P407
P577
2012-05-14T00:00:00Z