Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.
about
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinaseDistinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organsFunctional roles of Syk in macrophage-mediated inflammatory responsesThe growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion featuresThe Cbl interactome and its functionsThe BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation.FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.E3 ubiquitin ligase Cbl-b in innate and adaptive immunity.Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization.Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice.Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes.Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.Ubiquitin ligases in malignant lymphoma.Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma.A comprehensive map of the toll-like receptor signaling network.Regulation of the mast cell response to the type 1 Fc epsilon receptor.Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunityUbiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.Modulation of peripheral B cell tolerance by CD72 in a murine model.Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammationRegulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis.Cbl family proteins: balancing FcεRI-mediated mast cell and basophil activation.Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?Signaling mechanisms regulating B-lymphocyte activation and tolerance.Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis.Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264.E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation.CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα.Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance.Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals.
P2860
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P2860
Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
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2003年學術文章
@zh-hant
name
Cbl-b negatively regulates B c ...... on of the tyrosine kinase Syk.
@ast
Cbl-b negatively regulates B c ...... on of the tyrosine kinase Syk.
@en
type
label
Cbl-b negatively regulates B c ...... on of the tyrosine kinase Syk.
@ast
Cbl-b negatively regulates B c ...... on of the tyrosine kinase Syk.
@en
prefLabel
Cbl-b negatively regulates B c ...... on of the tyrosine kinase Syk.
@ast
Cbl-b negatively regulates B c ...... on of the tyrosine kinase Syk.
@en
P2093
P2860
P356
P1476
Cbl-b negatively regulates B c ...... on of the tyrosine kinase Syk.
@en
P2093
Hae Won Sohn
Susan K Pierce
P2860
P304
P356
10.1084/JEM.20021686
P407
P577
2003-05-27T00:00:00Z