The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.
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Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.CD154-CD40 interactions in the control of murine B cell hematopoiesisPathogen-Reactive T Helper Cell Analysis in the PigIn vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells.Post-transcriptional regulation in lymphocytes: the case of CD154Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responsesAntibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules.Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival.Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivoA repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFN-gamma but not IL-4.Th1 and Th2 cells help CD8 T-cell responses.Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Δ(9)-tetrahydrocannabinol in human CD4(+) T cells.Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on cell division and Th1/Th2 cytokine productionEffects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitroHuman CD14hi monocytes and myeloid dendritic cells provide a cell contact-dependent costimulatory signal for early CD40 ligand expressionDeregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients.Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease.Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific mannerThe effect of age on the cognate function of CD4+ T cells.SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responsesGlucocorticoid-induced TNFR-related protein stimulation reverses cardiac allograft acceptance induced by CD40-CD40L blockade.SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation.CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza.Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells.Transplant acceptance following anti-CD4 versus anti-CD40L therapy: evidence for differential maintenance of graft-reactive T cells.Tuning of CD40-CD154 interactions in human B-lymphocyte activation: a broad array of in vitro models for a complex in vivo situation.Co-culture of the 55-6 B cell hybridoma with the EL-4 thymoma cell. Effect on cell growth and monoclonal antibody production.Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells.Constitutive CD40 Signaling Calibrates Differentiation Outcomes in Responding B Cells via Multiple Molecular Pathways.NF-kappaB is involved in regulation of CD40 ligand expression on Mycobacterium bovis bacillus Calmette-Guérin-activated human T cells.Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in MiceA comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning.Characterizing the dynamics of CD4+ T cell priming within a lymph node.Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells.Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells.Peripheral blood CD27+ IgG+ B cells rapidly proliferate and differentiate into immunoglobulin-secreting cells after exposure to low CD154 interaction.
P2860
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P2860
The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
The biological outcome of CD40 ...... interleukin (IL)-4 and IL-12.
@ast
The biological outcome of CD40 ...... interleukin (IL)-4 and IL-12.
@en
type
label
The biological outcome of CD40 ...... interleukin (IL)-4 and IL-12.
@ast
The biological outcome of CD40 ...... interleukin (IL)-4 and IL-12.
@en
prefLabel
The biological outcome of CD40 ...... interleukin (IL)-4 and IL-12.
@ast
The biological outcome of CD40 ...... interleukin (IL)-4 and IL-12.
@en
P2093
P2860
P356
P1476
The biological outcome of CD40 ...... interleukin (IL)-4 and IL-12.
@en
P2093
Byung O Lee
Laura Haynes
Sheri M Eaton
Troy D Randall
P2860
P304
P356
10.1084/JEM.20020845
P407
P577
2002-09-01T00:00:00Z