Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration
about
Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectinsThrombus formation in vivo.Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flowPSGL-1 derived from human neutrophils is a high-efficiency ligand for endothelium-expressed E-selectin under flowBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseActivated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectinComparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters.P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules.CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo.Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.Mechanisms and consequences of neutrophil interaction with the endothelium.P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow.Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium.An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking.Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in miceComplete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity.Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin.Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy.Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration.The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cellsImportant role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host diseaseApplication of proteomics to neutrophil biologyTyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo.Two by two: the pairings of P-selectin and P-selectin glycoprotein ligand 1.Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1.E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling.Correlating the kinetics of cytokine-induced E-selectin adhesion and expression on endothelial cellsCurrent concepts in lymphocyte homing and recirculation.Adhesion receptors on haematopoietic progenitor cells.A semianalytical model to study the effect of cortical tension on cell rolling.Leukocyte extravasation: an immunoregulatory role for alpha-L-fucosidase?Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulumRegulation and migratory role of P-selectin ligands during intestinal inflammation.Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cellsFoxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment.P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice.
P2860
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P2860
Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Targeted gene disruption demon ...... utrophil rolling and migration
@ast
Targeted gene disruption demon ...... utrophil rolling and migration
@en
type
label
Targeted gene disruption demon ...... utrophil rolling and migration
@ast
Targeted gene disruption demon ...... utrophil rolling and migration
@en
prefLabel
Targeted gene disruption demon ...... utrophil rolling and migration
@ast
Targeted gene disruption demon ...... utrophil rolling and migration
@en
P2093
P2860
P356
P1476
Targeted gene disruption demon ...... utrophil rolling and migration
@en
P2093
B Tchernychev
E Williams
G Merrill-Skoloff
R Flaumenhaft
P2860
P304
P356
10.1084/JEM.190.12.1769
P407
P577
1999-12-01T00:00:00Z