Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma - Wikidata - wikimedia - TriplyDB

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

http://www.wikidata.org/entity/Q36377337

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Hazardous air pollutants and asthma.Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review.Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues Re-defining the unique roles for eosinophils in allergic respiratory inflammation Stromal cell regulation of homeostatic and inflammatory lymphoid organogenesis Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation The construction of transgenic and gene knockout/knockin mouse models of human disease Monoclonal antibodies and other biologic agents in the treatment of asthma Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle Genetically manipulated mouse models of lung disease: potential and pitfalls Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring Eosinophils in fungus-associated allergic pulmonary disease Reduced tumor necrosis factor-alpha and transforming growth factor-beta1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor alpha chain-deficient mice The immune profile associated with acute allergic asthma accelerates clearance of influenza virus A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice.Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy.Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.Cytokines in asthma.The macroimportance of the pulmonary immune microenvironment.Airway remodeling in asthma An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness The role of allergy in the development of asthma.Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice.Fundamental signals that regulate eosinophil homing to the gastrointestinal tract Airway remodeling in asthma. Unanswered questions.Asthma mediators: current views.Trophic slime, allergic slime.Interleukin-5, a therapeutic target in allergic inflammation Prevention of adult asthma by early intervention during childhood: potential value of new generation immunomodulatory drugs.Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways.Murine models of inflammation: role of CD23.What targeting eosinophils has taught us about their role in diseases.Animal models of asthma: potential usefulness for studying health effects of inhaled particles.Neuronal nitric oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.

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Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

http://www.wikidata.org/entity/Q36377337

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Journal of Experimental Medicine

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E W Gelfand

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I E Brenneise

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J J Lee

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K A Larson

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K L Denzler

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M A Horton

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M P McGarry

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N A Lee

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P E Carrigan

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S C Farmer

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P2860

Cloning of the murine eosinophil peroxidase gene (mEPO): characterization of a conserved subgroup of mammalian hematopoietic peroxidases

Eosinophilic Inflammation in Asthma

Cell-specific expression of a Clara cell secretory protein-human growth hormone gene in the bronchiolar epithelium of transgenic mice.

Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness.

A genome-wide search for quantitative trait loci underlying asthma.

Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion.

Eosinophils in asthma.

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

Eosinophilia in transgenic mice expressing interleukin 5.

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.

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2143-2156

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George D Leikauf

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273559259

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