Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.
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The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicingFibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteinsRegulation of cell motility by mitogen-activated protein kinaseDistinct gene expression profiles in immortalized human urothelial cells exposed to inorganic arsenite and its methylated trivalent metabolitesWest Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of v 3 IntegrinRegulation of tumor cell chemotaxis by type IV collagen is mediated by a Ca(2+)-dependent mechanism requiring CD47 and the integrin alpha(V)beta(3)Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunitThe role of conserved amino acid motifs within the integrin beta3 cytoplasmic domain in triggering focal adhesion kinase phosphorylationA Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast functionProtein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.Disruption of C-terminal cytoplasmic domain of betaPS integrin subunit has dominant negative properties in developing Drosophila.Cytoskeletal interactions with the leukocyte integrin beta2 cytoplasmic tail. Activation-dependent regulation of associations with talin and alpha-actininThe N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism.Integrins: a role as cell signalling molecules.Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGFInduction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway.Growth factor receptor tyrosine kinases: cell adhesion kinase family suggests a novel signaling mechanism in cancer.Myosin-X provides a motor-based link between integrins and the cytoskeleton.Matrix metalloproteinase-2 promotes αvβ3 integrin-mediated adhesion and migration of human melanoma cells by cleaving fibronectin.Mechanisms of tumour invasion and metastasis: emerging targets for therapy.Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic virusesThe alpha v integrin antagonists as novel anticancer agents: an update.Integrin-dependent pathologies.HARE-Mediated Endocytosis of Hyaluronan and Heparin Is Targeted by Different Subsets of Three Endocytic Motifs.A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor.In vivo optical imaging of integrin alphaV-beta3 in mice using multivalent or monovalent cRGD targeting vectors.Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs.Syndecan-1 mediates cell spreading in transfected human lymphoblastoid (Raji) cells.Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding.Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinaseActivation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3.Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domain.Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins.Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migrationApplication of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen.Cloning and characterization of a novel integrin beta3 subunit.Use of a beta1 integrin-deficient human T cell to identify beta1 integrin cytoplasmic domain sequences critical for integrin function.
P2860
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P2860
Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Requirement of the NPXY motif ...... igration in vitro and in vivo.
@ast
Requirement of the NPXY motif ...... igration in vitro and in vivo.
@en
type
label
Requirement of the NPXY motif ...... igration in vitro and in vivo.
@ast
Requirement of the NPXY motif ...... igration in vitro and in vivo.
@en
prefLabel
Requirement of the NPXY motif ...... igration in vitro and in vivo.
@ast
Requirement of the NPXY motif ...... igration in vitro and in vivo.
@en
P2093
P2860
P356
P1476
Requirement of the NPXY motif ...... migration in vitro and in vivo
@en
P2093
D A Cheresh
P C Brooks
S L Deming
P2860
P304
P356
10.1083/JCB.130.2.441
P407
P577
1995-07-01T00:00:00Z