Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
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Recent developments in using mechanistic cardiac modelling for drug safety evaluationTreatment of non-muscle invasive bladder cancer with Bacillus Calmette-Guerin (BCG): Biological markers and simulation studiesBridging Systems Medicine and Patient NeedsComputer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesComputational model of erratic arrhythmias in a cardiac cell network: the role of gap junctionsChaste: an open source C++ library for computational physiology and biology.Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator.The Cardiac Electrophysiology Web LabPrediction of Thorough QT study results using action potential simulations based on ion channel screensIntegrative approaches to computational biomedicineTox-database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition.Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study.Mathematical modeling of physiological systems: an essential tool for discovery.Computational modeling of inhibition of voltage-gated Ca channels: identification of different effects on uterine and cardiac action potentials.Bayesian Sensitivity Analysis of a Cardiac Cell Model Using a Gaussian Process Emulator.The virtual heart as a platform for screening drug cardiotoxicity.In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual levelIn silico assessment of drug safety in human heart applied to late sodium current blockersCombining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies.Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology.Cardiac action potential repolarization re-visited: early repolarization shows all-or-none behaviour.Uncertainty and variability in computational and mathematical models of cardiac physiology.Ions, equations and electrons: the evolving role of computer simulations in cardiac electrophysiology safety evaluations.Replacing the thorough QT study: reflections of a baby in the bath water.Humans Vary, So Cardiac Models Should Account for That Too!Rigorous Phenotyping of Cardiac iPSC Preparations Requires Knowledge of Their Resting Potential(s).Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes.Uncertainty quantification of 2 models of cardiac electromechanics.In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology.Systems biology-embedded target validation: improving efficacy in drug discovery.
P2860
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P2860
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
@ast
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
@en
type
label
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
@ast
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
@en
prefLabel
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
@ast
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
@en
P2860
P50
P921
P1476
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing
@en
P2093
P2860
P304
P356
10.1111/J.1476-5381.2012.02020.X
P407
P577
2012-11-01T00:00:00Z