Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification - Wikidata - wikimedia - TriplyDB

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

http://www.wikidata.org/entity/Q36383859

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FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells Regulation of T Cell Differentiation and Function by EZH2 T cell receptor signalling in the control of regulatory T cell differentiation and function Disrupted regulatory T cell homeostasis in inflammatory bowel diseases Regulatory T Cells in Kidney Transplantation: New Directions?Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming Exploiting genomics and natural genetic variation to decode macrophage enhancers Minireview: Conversing with chromatin: the language of nuclear receptors Transplantation tolerance and its outcome during infections and inflammation Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers Epigenetic mechanisms and developmental choice hierarchies in T-lymphocyte development Super-enhancers: Asset management in immune cell genomes Regulatory cells and transplantation tolerance Towards an understanding of cell-specific functions of signal-dependent transcription factors FOXP3: genetic and epigenetic implications for autoimmunity Genetic and genomic approaches to understanding macrophage identity and function Regulatory T-cell therapy in transplantation: moving to the clinic The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.Histone Posttranslational Modifications of CD4⁺ T Cell in Autoimmune Diseases Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells The selection and function of cell type-specific enhancers Genetic and epigenetic fine mapping of causal autoimmune disease variants Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Ex vivo modulation of the Foxo1 phosphorylation state does not lead to dysfunction of T regulatory cells.Genome-wide predictors of NF-κB recruitment and transcriptional activity Genetic and epigenetic variation in the lineage specification of regulatory T cells.Once a Treg, always a Treg?β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.Self-specific memory regulatory T cells protect embryos at implantation in mice.Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells Designing an enhancer landscape.Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation.Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape.Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells.Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.Continuous requirement for the TCR in regulatory T cell function.Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes.

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Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

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Alex Reynolds

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Alexander Y Rudensky

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Jeong M Kim

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Ming O Li

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Steven Z Josefowicz

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Will Liao

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P2860

IPEX as a result of mutations in FOXP3

FOXP3 controls regulatory T cell function through cooperation with NFAT

Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor

The accessible chromatin landscape of the human genome

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

Control of pancreas and liver gene expression by HNF transcription factors

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta

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