Transcription errors induce proteotoxic stress and shorten cellular lifespan
about
Misincorporation by RNA polymerase is a major source of transcription pausing in vivoSelective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum.An MSC2 Promoter-lacZ Fusion Gene Reveals Zinc-Responsive Changes in Sites of Transcription Initiation That Occur across the Yeast Genome.Life span extension by targeting a link between metabolism and histone acetylation in Drosophila.RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modificationsThe control of translational accuracy is a determinant of healthy ageing in yeast.Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis.Transcriptional mutagenesis reduces splicing fidelity in mammalian cells.Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity.The transcription fidelity factor GreA impedes DNA break repair.A link between transcription fidelity and pausing in vivo.The landscape of transcription errors in eukaryotic cells.Commentary: The landscape of transcription errors in eukaryotic cells.Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and phage T7 single-subunit RNA polymerases.Rpb9-deficient cells are defective in DNA damage response and require histone H3 acetylation for survival.O6-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function.Somatic mutations in neurons during aging and neurodegeneration.Transcription fidelity and its roles in the cell.
P2860
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P2860
Transcription errors induce proteotoxic stress and shorten cellular lifespan
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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name
Transcription errors induce proteotoxic stress and shorten cellular lifespan
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Transcription errors induce proteotoxic stress and shorten cellular lifespan
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type
label
Transcription errors induce proteotoxic stress and shorten cellular lifespan
@ast
Transcription errors induce proteotoxic stress and shorten cellular lifespan
@en
prefLabel
Transcription errors induce proteotoxic stress and shorten cellular lifespan
@ast
Transcription errors induce proteotoxic stress and shorten cellular lifespan
@en
P2093
P2860
P50
P356
P1476
Transcription errors induce proteotoxic stress and shorten cellular lifespan
@en
P2093
Agnes Holczbauer
Ashley S Denney
Chao-Wei Hung
Daniel W Summers
Dorothy A Erie
Douglas Cyr
J Will Thompson
Jacob Gauer
James Jorgenson
Jeffrey N Strathern
P2860
P2888
P356
10.1038/NCOMMS9065
P407
P577
2015-08-25T00:00:00Z