Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. - Wikidata - wikimedia - TriplyDB

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.

http://www.wikidata.org/entity/Q36386431

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Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism Polycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular background Immunometabolism of regulatory T cells PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.Inhibition of histone methyltransferase EZH2 ameliorates early acute renal allograft rejection in rats GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells.MicroRNA-491 regulates the proliferation and apoptosis of CD8(+) T cells KLRG1 restricts memory T cell antitumor immunity.Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy.Reversing T-cell Dysfunction and Exhaustion in Cancer.Metabolic regulation of immune responses: therapeutic opportunities.T-cell metabolism governing activation, proliferation and differentiation; a modular view.Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey-Holden Prostate Cancer Academy Meeting.Epigenetic control of the tumor microenvironment.Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2.Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul.Immunometabolism in systemic lupus erythematosus.Visualizing the life of mRNA in T cells.Structure of the PRC2 complex and application to drug discovery.Epigenetic Variability in Systemic Lupus Erythematosus: What We Learned from Genome-Wide DNA Methylation Studies.Metabolic Instruction of Immunity.Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy.Transcriptional and epigenetic regulation of T cell hyporesponsiveness.The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia.ASIATIC ACID INFLUENCES GLUCOSE HOMEOSTASIS IN P. BERGHEI MURINE MALARIA INFECTED SPRAGUE-DAWLEY RATS.Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing.Epigenetic Reprogramming in Naive CD4+ T Cells Favoring T Cell Activation and Non-Th1 Effector T Cell Immune Response as an Early Event in Lupus Flares Immune Cell Population in Ovarian Tumor Microenvironment.The tumor microenvironment disarms CD8+ T lymphocyte function via a miR-26a-EZH2 axis.Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening.Immune checkpoint inhibitors in cancer therapy.Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.miRNAs, Melanoma and Microenvironment: An Intricate Network.Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease.

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Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.

http://www.wikidata.org/entity/Q36386431

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2015年學術文章

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2015年學術文章

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2015年學術文章

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Cancer mediates effector T cel ...... H2 via glycolysis restriction.

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Cancer mediates effector T cel ...... H2 via glycolysis restriction.

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Cancer mediates effector T cel ...... H2 via glycolysis restriction.

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Cancer mediates effector T cel ...... H2 via glycolysis restriction.

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Nature Immunology

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Arul M Chinnaiyan

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Ende Zhao

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Guobin Wang

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Hongbo Wang

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Ilona Kryczek

http://www.w3.org/2001/XMLSchema#string

Irene Shao

http://www.w3.org/2001/XMLSchema#string

Jan Kotarski

http://www.w3.org/2001/XMLSchema#string

Ke Wu

http://www.w3.org/2001/XMLSchema#string

Lili Zhao

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Linda Vatan

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P2860

Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

The Polycomb group protein EZH2 directly controls DNA methylation

Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization

Posttranscriptional control of T cell effector function by aerobic glycolysis

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

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10.1038/NI.3313

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1

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Sooryanarayana Varambally

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283456950

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