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Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice

Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice

http://www.wikidata.org/entity/Q36388809

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Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies Transgenic Models in Retinoblastoma Research Single and Multiple Gene Manipulations in Mouse Models of Human Cancer Twists in views on RB functions in cellular signaling, metabolism and stem cells Newly identified aspects of tumor suppression by RB Pediatric solid tumor genomics and developmental pliancy Mitosis in neurons: Roughex and APC/C maintain cell cycle exit to prevent cytokinetic and axonal defects in Drosophila photoreceptor neurons Heterogenic final cell cycle by chicken retinal Lim1 horizontal progenitor cells leads to heteroploid cells with a remaining replicated genome Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression Transcriptional control of stem cell fate by E2Fs and pocket proteins TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning.Retinal progenitor cells can produce restricted subsets of horizontal cells.Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells.Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf.Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina.Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells p107 in the public eye: an Rb understudy and more.A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo.Differential gene expression profile of retinoblastoma compared to normal retina Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression.Development of the retina and optic pathway.Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes Retinoblastoma. Fifty years of progress. The LXXI Edward Jackson Memorial Lecture.The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway Characterization of the cell of origin for small cell lung cancer Neuronal cell cycle: the neuron itself and its circumstances Development and neurogenic potential of Müller glial cells in the vertebrate retina.Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma.The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency.The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells The retinoblastoma tumor suppressor and stem cell biology.Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma.Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays.The Zebrafish Anillin-eGFP Reporter Marks Late Dividing Retinal Precursors and Stem Cells Entering Neuronal Lineages

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Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice

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Itsuki Ajioka

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P2860

Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina

Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

Compensation by tumor suppressor genes during retinal development in mice and humans.

The biology of chronic myeloid leukemia.

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.

A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina.

Potential for neural regeneration after neurotoxic injury in the adult mammalian retina.

The search for the retinoblastoma cell of origin.

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