Glucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease.
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Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's diseaseGaucher disease and comorbidities: B-cell malignancy and parkinsonismAmbroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cellsTool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysatesThe role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies.Neural differentiation modulates the vertebrate brain specific splicing programNanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregatesStrong association between glucocerebrosidase mutations and Parkinson's disease in Sweden.Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.Glucocerebrosidase in Parkinson's disease: Insights into pathogenesis and prospects for treatment.Induced Pluripotent Stem Cell Modeling of Gaucher's Disease: What Have We Learned?Glucocerebrosidase expression patterns in the non-human primate brain.The genetic architecture of mitochondrial dysfunction in Parkinson's disease.Lysosomal defects in ATP13A2 and GBA associated familial Parkinson's disease.Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood.
P2860
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P2860
Glucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Glucocerebrosidase mutations a ...... ysosomes in Lewy body disease.
@ast
Glucocerebrosidase mutations a ...... ysosomes in Lewy body disease.
@en
type
label
Glucocerebrosidase mutations a ...... ysosomes in Lewy body disease.
@ast
Glucocerebrosidase mutations a ...... ysosomes in Lewy body disease.
@en
prefLabel
Glucocerebrosidase mutations a ...... ysosomes in Lewy body disease.
@ast
Glucocerebrosidase mutations a ...... ysosomes in Lewy body disease.
@en
P2093
P2860
P1476
Glucocerebrosidase mutations a ...... ysosomes in Lewy body disease.
@en
P2093
Christopher M Morris
Debra J Lett
Ian G McKeith
Peter G Blain
Peter S Hanson
P2860
P304
P356
10.1111/J.1471-4159.2012.07879.X
P407
P577
2012-08-22T00:00:00Z