Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. - Wikidata - wikimedia - TriplyDB

Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense.

Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense.

http://www.wikidata.org/entity/Q36399526

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Aging of the immune system: how much can the adaptive immune system adapt?Immunosenescence: emerging challenges for an ageing population Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression Acquired and intrinsic resistance in cancer immunotherapy Immunosenescence and organ transplantation T cell replicative senescence in human aging Key role of T cell defects in age-related vulnerability to West Nile virus Immunosenescence: deficits in adaptive immunity in the elderly Prolonged graft survival in older recipient mice is determined by impaired effector T-cell but intact regulatory T-cell responses Effects of aging on the adaptive immune response to respiratory virus infections.Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling.Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.Functional CD8 T cell memory responding to persistent latent infection is maintained for life.Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection.Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.Inflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens.Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study.The narrowing of the CD8 T cell repertoire in old age Coordinated regulation of NK receptor expression in the maturing human immune system.Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses.Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells.Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques.Age-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naïve T lymphocytes.Narrowing of human influenza A virus-specific T cell receptor α and β repertoires with increasing age.Quantitative analysis of T cell receptor diversity in clinical samples of human peripheral blood.T-cell biology in aging, with a focus on lung disease.Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice.CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome The relationship of cytomegalovirus (CMV) infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in human aging.Aging and CD8+ T cell immunity to respiratory virus infections.T cell aging: naive but not young.Elevated HbA(1c) levels and the accumulation of differentiated T cells in CMV(+) individuals Non-malignant clonal expansions of CD8+ memory T cells in aged individuals.Human immunosenescence: is it infectious?Sex and Gender Impact Immune Responses to Vaccines Among the Elderly Changes in peripheral blood immune cell composition in osteoarthritis.Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates.Donor CD4 T Cell Diversity Determines Virus Reactivation in Patients After HLA-Matched Allogeneic Stem Cell Transplantation

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P2860

Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense.

http://www.wikidata.org/entity/Q36399526

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Age-related CD8 T cell clonal ...... tial to impair immune defense.

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Age-related CD8 T cell clonal ...... tial to impair immune defense.

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type

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Age-related CD8 T cell clonal ...... tial to impair immune defense.

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Age-related CD8 T cell clonal ...... tial to impair immune defense.

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prefLabel

Age-related CD8 T cell clonal ...... tial to impair immune defense.

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Age-related CD8 T cell clonal ...... tial to impair immune defense.

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Journal of Experimental Medicine

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Age-related CD8 T cell clonal ...... tial to impair immune defense.

@en

P2093

Beatrix M Metzner

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Ilhem Messaoudi

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Jose A Guevara-Patino

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Joël Lemaoult

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P2860

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

T cell receptor antagonist peptides induce positive selection

The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant.

Ageing of lymphocytes and lymphocytes in the aged.

TCR peptide therapy in human autoimmune diseases.

Peripheral selection of the T cell repertoire.

The many important facets of T-cell repertoire diversity.

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

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1347-1358

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scholarly article

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10.1084/JEM.20040437

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10

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200

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Janko Nikolich-Žugich

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2004-11-01T00:00:00Z

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8182372

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15545358

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2211915

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