Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture
about
Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74Molecular virology of Kaposi's sarcoma-associated herpesvirusKaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicityEpstein-Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor.Constitutive signaling by Kaposi's sarcoma-associated herpesvirus G-protein-coupled receptor desensitizes calcium mobilization by other receptors.The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor.Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma.Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirusPatterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirusModulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.Chemokine receptor internalization and intracellular trafficking.Lymphatic reprogramming by Kaposi sarcoma herpes virus promotes the oncogenic activity of the virus-encoded G-protein-coupled receptor.Desensitization of herpesvirus-encoded G protein-coupled receptors.The chemokine receptor homologue encoded by US27 of human cytomegalovirus is heavily glycosylated and is present in infected human foreskin fibroblasts and enveloped virus particles.Targeted therapy for Kaposi sarcoma.New drug targets in Kaposi sarcoma.Dual role of GRK5 in cancer development and progression.The genome of a very virulent Marek's disease virus.The genome of turkey herpesvirusThe Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells.Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.
P2860
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P2860
Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture
description
1998 nî lūn-bûn
@nan
1998年の論文
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1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
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name
Inhibition of constitutive sig ...... in mammalian cells in culture
@ast
Inhibition of constitutive sig ...... in mammalian cells in culture
@en
type
label
Inhibition of constitutive sig ...... in mammalian cells in culture
@ast
Inhibition of constitutive sig ...... in mammalian cells in culture
@en
prefLabel
Inhibition of constitutive sig ...... in mammalian cells in culture
@ast
Inhibition of constitutive sig ...... in mammalian cells in culture
@en
P2093
P2860
P356
P1476
Inhibition of constitutive sig ...... in mammalian cells in culture
@en
P2093
E Cesarman
E Geras-Raaka
L Arvanitakis
M C Gershengorn
P2860
P304
P356
10.1084/JEM.187.5.801
P407
P577
1998-03-01T00:00:00Z