14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
about
The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Targeting 14-3-3 adaptor protein-protein interactions to stimulate central nervous system repair.PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.Mechanisms of Mutant LRRK2 Neurodegeneration.LRRK2 Phosphorylation.
P2860
Q33905778-34686EBC-1148-4E77-9052-61B47BB9AAA6Q38684995-31537F70-4DF7-4573-B836-595D3FD5C103Q38814476-6291F51A-E3BF-4104-B730-B8D1BFAA803EQ41429757-3F1C7661-D07A-4442-AC90-A197DCBE371BQ47222316-E1BD82E6-1B1D-41D0-8BB0-24603BEFBBCDQ48239635-20FED93B-B965-47B1-9530-482903194495Q51082156-C5D8B716-3E64-410B-87FD-95722AE096FC
P2860
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
@ast
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
@en
type
label
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
@ast
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
@en
prefLabel
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
@ast
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
@en
P2093
P2860
P356
P1476
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening
@en
P2093
Huiping Ding
Nicholas J Lavalley
Sunny R Slone
Talene A Yacoubian
P2860
P304
P356
10.1093/HMG/DDV453
P577
2015-11-05T00:00:00Z