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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

http://www.wikidata.org/entity/Q36402678

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Negative regulation of cytokine signaling and immune responses by SOCS proteins Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes SOCS, inflammation, and cancer The role of suppressors of cytokine signalling in human neoplasms Gene expression and hepatitis C virus infection Liver fibrosis From the bench to the clinic and back again: translational biomarker discovery using in silico mining of pharmacogenomic data.SOCS1 is a negative regulator of metabolic reprogramming during sepsis Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-β.SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases.Quantitative analysis of interferon alpha receptor subunit 1 and suppressor of cytokine signaling 1 gene transcription in blood cells of patients with chronic hepatitis C.Correlation analysis of liver tumor-associated genes with liver regeneration Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies.An integrated analysis of SOCS1 down-regulation in HBV infection-related hepatocellular carcinoma.Animal models for the study of liver fibrosis: new insights from knockout mouse models.In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins.Association of SOCS1 (- 820) (rs33977706) gene polymorphism with chronic periodontitis: A case-control study in Brazilians SOCS, Inflammation, and Autoimmunity.Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice Experimental models of liver fibrosis Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3 Signal transduction of inflammatory cytokines and tumor development.Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice.miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1 Immune gene expression in swine macrophages expressing the Torque Teno Sus Virus1 (TTSuV1) ORF-1 and 2 proteins.SOCS regulation of the JAK/STAT signalling pathway.Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.DNA methylation in hepatocellular carcinoma.Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance.Revisiting steroid treatment for septic shock: molecular actions and clinical effects--a review.New surprises of suppressor of cytokine signalling in liver fibrosis.Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity.Dietary gossypol suppressed postprandial TOR signaling and elevated ER stress pathways in turbot (Scophthalmus maximus L.).Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver.Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma.Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells.SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis.Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.

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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

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Journal of Experimental Medicine

P1476

SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

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Akihiko Yoshimura

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Akiko Joo

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Hiroshi Shiraishi

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Hisaki Nagai

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Hisanobu Ogata

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Masaki Kamio

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Michio Sata

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Takafumi Yoshida

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Yoko Tokunaga

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P2860

A family of cytokine-inducible inhibitors of signalling

A new protein containing an SH2 domain that inhibits JAK kinases

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

Negative regulation of cytokine signaling pathways

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

Structure and function of a new STAT-induced STAT inhibitor

An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group

Hepatocellular carcinoma and hepatitis C in the United States.

Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.

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1701-1707

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10.1084/JEM.20031675

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15197228

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