XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
about
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cellsInvolvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseasesFactors regulating immunoglobulin production by normal and disease-associated plasma cellsThe involvement of SMILE/TMTC3 in endoplasmic reticulum stress responseProgressively impaired proteasomal capacity during terminal plasma cell differentiation.Regulated increase in folding capacity prevents unfolded protein stress in the ER.XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response.Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein responseLack of XBP-1 impedes murine cytomegalovirus gene expression.The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells.Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin.Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation.Low concentrations of corticosterone exert stimulatory effects on macrophage function in a manner dependent on glucocorticoid receptors.Bcl-2 family on guard at the ER.Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.Emerging roles for XBP1, a sUPeR transcription factor.Development of a fluorescent reporter system for monitoring ER stress in Chinese hamster ovary cells and its application for therapeutic protein productionThe Unfolded Protein Response in Homeostasis and Modulation of Mammalian Immune Cells.The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat.Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1.Depletion of hsp90beta induces multiple defects in B cell receptor signaling.Physiological/pathological ramifications of transcription factors in the unfolded protein response.Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cellsCoordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.Role of the unfolded protein response in organ physiology: lessons from mouse models.
P2860
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P2860
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
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2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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name
XBP-1 specifically promotes Ig ...... ycoproteins in primary B cells
@ast
XBP-1 specifically promotes Ig ...... ycoproteins in primary B cells
@en
type
label
XBP-1 specifically promotes Ig ...... ycoproteins in primary B cells
@ast
XBP-1 specifically promotes Ig ...... ycoproteins in primary B cells
@en
prefLabel
XBP-1 specifically promotes Ig ...... ycoproteins in primary B cells
@ast
XBP-1 specifically promotes Ig ...... ycoproteins in primary B cells
@en
P2093
P2860
P356
P1476
XBP-1 specifically promotes Ig ...... ycoproteins in primary B cells
@en
P2093
Boaz Tirosh
Hidde L Ploegh
Laurie H Glimcher
Neal N Iwakoshi
P2860
P304
P356
10.1084/JEM.20050575
P407
P577
2005-08-01T00:00:00Z