Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans.
about
Fc glycans of therapeutic antibodies as critical quality attributesChemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan BiosynthesisAssessing Analytical Similarity of Proposed Amgen Biosimilar ABP 501 to AdalimumabHigh-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation.Predicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey.Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties.Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2011-2012.N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical.The criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development.Recent advances in the understanding of biological implications and modulation methodologies of monoclonal antibody N-linked high mannose glycans.Post-translational structural modifications of immunoglobulin G and their effect on biological activity.Biosimilarity Versus Manufacturing Change: Two Distinct Concepts.Arabinosylation of recombinant human immunoglobulin-based protein therapeuticsState-of-the-art technologies for rapid and high-throughput sample preparation and analysis of N-glycans from antibodies.Impact of IgG Fc-Oligosaccharides on Recombinant Monoclonal Antibody Structure, Stability, Safety, and Efficacy.Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins.A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation.Drifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilarReal-time product attribute control to manufacture antibodies with defined N-linked glycan levels.Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates.Pharmacokinetics of Monoclonal Antibodies.Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity.Main Quality Attributes of Monoclonal Antibodies and Effect of Cell Culture ComponentsMannose metabolism in recombinant CHO cells and its effect on IgG glycosylation.A robust method for increasing Fc glycan high mannose level of recombinant antibodies.Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody.Impact of host cell line choice on glycan profile.Alga-Made Anti-Hepatitis B Antibody Binds to Human Fcγ Receptors.Structural characterization of the Man5 glycoform of human IgG3 Fc.Controlling the time evolution of mAb N-linked glycosylation, Part I: Microbioreactor experiments.Biosimilarity and Interchangeability: Principles and Evidence: A Systematic Review.Assessment of structural and functional similarity of biosimilar products: Rituximab as a case study.Glycan characterization of the NIST RM monoclonal antibody using a total analytical solution: From sample preparation to data analysis.A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies.Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function.Monensin, a small molecule ionophore, can be used to increase high mannose levels on monoclonal antibodies generated by Chinese hamster ovary production cell-lines.Modulation of mAb quality attributes using microliter scale fed-batch cultures.Analytical comparability study of recombinant monoclonal antibody therapeutics.Improving Immunotherapy Through Glycodesign
P2860
Q26799266-FB16CF10-3CE3-40E7-8F55-CFBB43F86E09Q27673777-C42DC49A-F421-4342-BD8F-AB5B12E16C88Q28831404-C3000B1A-E0C2-48B2-9955-5E285360C39DQ30675226-576C19AA-09BD-4F11-BDD7-461EB706EF6FQ31091923-DECFCDBD-12CB-4BB8-81CE-01EC1A4123B4Q33551688-E448BDCF-1C67-4DF6-A527-2BE1BFF577CFQ34489424-B7C74D7B-FB32-4FA6-9C87-AD150CD55C75Q36133312-9953579F-04ED-4561-8ABE-D16EA26CE457Q36213158-FFDCE794-3B76-4722-87F1-6E954DB5E2C9Q38224264-2186983A-2902-4969-A06B-7CCD106E8197Q38246996-8D8A08F1-F38A-4773-AFCB-AE96809E157CQ38588544-1267B4DE-0592-4DCB-8385-36F3142E9CE2Q38709004-74534B51-41B9-4EBF-98E6-FA17F65DFF39Q38717803-859A951E-FB2F-4A79-A138-A8F75B2FECFFQ38762019-5B6458EC-E692-4DE3-9308-3C982EF03A08Q38831148-2BC62D37-CEDE-4407-AE20-8241FF565469Q38849069-E8880052-2145-4A9D-ACA1-408D90599E8AQ38906179-4624B36B-484F-480F-AEBA-B0CEDB57FE20Q38984304-4CB2ABB8-0263-4AA0-A591-2C455DCFBB69Q39277950-843D70A9-5BEE-431B-A92D-6C6071A17ED9Q42118646-045416CB-4EE9-4C99-B84A-6FD3C24B2FDBQ42129626-6E68D5E4-5119-4B2F-B101-BCDCA203DFCAQ42363063-B60584AD-39C9-4F64-9705-34B27B12B25DQ46021617-E135D20D-684F-4C42-BFB8-52E4944D2F7DQ46115076-0219A3AC-1375-4729-8C24-18834301ADF8Q46866013-379131C0-2601-4DCE-8E39-CBFA8A67A16AQ47269842-22CBEF38-8BD7-495F-BD0E-FC53EE31742EQ47341896-63C05458-982D-4A3C-9A9A-3C5CA373EE50Q47445247-402162FD-5EFD-4A39-8BCA-CC470C492838Q47656437-98494BE4-9E6C-453C-AA3A-E7EC755B93CDQ49979586-D862BC20-185F-41F1-A8B4-5C6B610F3CA1Q50098437-B3EAB77E-35FD-466D-800F-09F3610996A6Q50140582-02B16CCB-4A55-4C11-A273-C8263FBC495CQ50199955-A7AF8A81-2AA1-4A4E-8D2F-BA2211D96AD5Q50200755-DF5405D1-2B9D-4E95-9E37-3DFA23BD0DB6Q51744834-379D4BDE-8EA8-4C93-8F27-B76D2BE0542BQ51749017-28DB5360-5410-43E1-BDFF-08FA7DF6AC1FQ52669512-6A62474E-FBB2-4131-AC25-63481BF8B171Q59132146-A7C39AE6-D677-4A18-973D-ABF6DCB6950C
P2860
Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Production, characterization, ...... th N-linked mannose-5 glycans.
@ast
Production, characterization, ...... th N-linked mannose-5 glycans.
@en
type
label
Production, characterization, ...... th N-linked mannose-5 glycans.
@ast
Production, characterization, ...... th N-linked mannose-5 glycans.
@en
prefLabel
Production, characterization, ...... th N-linked mannose-5 glycans.
@ast
Production, characterization, ...... th N-linked mannose-5 glycans.
@en
P2093
P2860
P356
P1476
Production, characterization, ...... th N-linked mannose-5 glycans.
@en
P2093
Darren Brown
Eric Stefanich
Jean-Philippe Stephan
Jeff Lutman
Marcella Yu
Robert Bayer
Shan Chung
P2860
P304
P356
10.4161/MABS.20737
P577
2012-07-01T00:00:00Z