I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. - Wikidata - wikimedia - TriplyDB

I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.

I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.

http://www.wikidata.org/entity/Q36402985

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A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway Signaling Pathways in Osteoclast Differentiation Regulation of NFATc1 in Osteoclast Differentiation Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity OCLI-023, a Novel Pyrimidine Compound, Suppresses Osteoclastogenesis In Vitro and Alveolar Bone Resorption In Vivo NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism.Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.(-)-Epicatechin 3-O-β-D-allopyranoside prevent ovariectomy-induced bone loss in mice by suppressing RANKL-induced NF-κB and NFATc-1 signaling pathways.NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development.IκB kinase β regulates epithelium migration during corneal wound healing Carboxyl terminus of Hsp70-interacting protein regulation of osteoclast formation in mice through promotion of tumor necrosis factor receptor-associated factor 6 protein degradation.Etiopathogenesis of mandibulofacial and maxillofacial abscesses in mice.Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis TRP14 inhibits osteoclast differentiation via its catalytic activity M-CSF induces monocyte survival by activating NF-κB p65 phosphorylation at Ser276 via protein kinase C.WITHDRAWN: Cardamonin Inhibits Osteoclastogenesis Induced by Tumor Cells Through Interruption of the Signaling Pathway Activated by Receptor Activator of NF-κB Ligand.Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway Constitutively active canonical NF-κB pathway induces severe bone loss in mice.RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.Novel functions for NFκB: inhibition of bone formation Osteoclasts; culprits in inflammatory osteolysis.Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.NF-κB-Mediated Regulation of Osteoclastogenesis Role of NF-κB in the skeleton IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5.Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling Inhibitory effect of ribbon-type NF-kappaB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis Receptor activator of nuclear factor-κB ligand (RANKL) protects against hepatic ischemia/reperfusion injury in mice.Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling RNA therapeutics targeting osteoclast-mediated excessive bone resorption.Regulation by Phloroglucinol of Nrf2/Maf-Mediated Expression of Antioxidant Enzymes and Inhibition of Osteoclastogenesis via the RANKL/RANK Signaling Pathway: In Silico study.Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO.Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug.NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.

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P2860

I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.

http://www.wikidata.org/entity/Q36402985

description

2005 nî lūn-bûn

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.

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I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.

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I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.

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I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.

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I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.

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I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.

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Jin Mo Park

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Maria Grazia Ruocco

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Shin Maeda

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Toby Lawrence

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Yixue Cao

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P2860

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

RANK is essential for osteoclast and lymph node development

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway

Toll-like receptors

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

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