I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
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A comprehensive manually curated reaction map of RANKL/RANK-signaling pathwaySignaling Pathways in Osteoclast DifferentiationRegulation of NFATc1 in Osteoclast DifferentiationCutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivityOCLI-023, a Novel Pyrimidine Compound, Suppresses Osteoclastogenesis In Vitro and Alveolar Bone Resorption In VivoNFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism.Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.(-)-Epicatechin 3-O-β-D-allopyranoside prevent ovariectomy-induced bone loss in mice by suppressing RANKL-induced NF-κB and NFATc-1 signaling pathways.NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development.IκB kinase β regulates epithelium migration during corneal wound healingCarboxyl terminus of Hsp70-interacting protein regulation of osteoclast formation in mice through promotion of tumor necrosis factor receptor-associated factor 6 protein degradation.Etiopathogenesis of mandibulofacial and maxillofacial abscesses in mice.Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesisTRP14 inhibits osteoclast differentiation via its catalytic activityM-CSF induces monocyte survival by activating NF-κB p65 phosphorylation at Ser276 via protein kinase C.WITHDRAWN: Cardamonin Inhibits Osteoclastogenesis Induced by Tumor Cells Through Interruption of the Signaling Pathway Activated by Receptor Activator of NF-κB Ligand.Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathwayConstitutively active canonical NF-κB pathway induces severe bone loss in mice.RANKL signaling and osteoclastogenesis is negatively regulated by cardamoninWater extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorptionp62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.Novel functions for NFκB: inhibition of bone formationOsteoclasts; culprits in inflammatory osteolysis.Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.NF-κB-Mediated Regulation of OsteoclastogenesisRole of NF-κB in the skeletonIKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5.Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signalingInhibitory effect of ribbon-type NF-kappaB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivoPositive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritisReceptor activator of nuclear factor-κB ligand (RANKL) protects against hepatic ischemia/reperfusion injury in mice.Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signalingRNA therapeutics targeting osteoclast-mediated excessive bone resorption.Regulation by Phloroglucinol of Nrf2/Maf-Mediated Expression of Antioxidant Enzymes and Inhibition of Osteoclastogenesis via the RANKL/RANK Signaling Pathway: In Silico study.Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO.Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysisAmlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug.NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
P2860
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P2860
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.
@ast
I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.
@en
type
label
I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.
@ast
I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.
@en
prefLabel
I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.
@ast
I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.
@en
P2093
P2860
P50
P356
P1476
I{kappa}B kinase (IKK){beta}, ...... nflammation-induced bone loss.
@en
P2093
Jin Mo Park
Maria Grazia Ruocco
Shin Maeda
Toby Lawrence
P2860
P304
P356
10.1084/JEM.20042081
P407
P577
2005-05-01T00:00:00Z