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Advances in combating fungal diseases: vaccines on the threshold

Advances in combating fungal diseases: vaccines on the threshold

http://www.wikidata.org/entity/Q36406460

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New insights on the development of fungal vaccines: from immunity to recent challenges Studies of Immune Responses in Candida vaginitis Dendritic cells in antifungal immunity and vaccine design Adaptive immunity to fungi The human mycobiome in health and disease Evaluation of two homologous proline-rich proteins of Coccidioides posadasii as candidate vaccines against coccidioidomycosis Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence An altered camelid-like single domain anti-idiotypic antibody fragment of HM-1 killer toxin: acts as an effective antifungal agent.FungalRV: adhesin prediction and immunoinformatics portal for human fungal pathogens.Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control Horizontal transmission of Candida albicans and evidence of a vaccine response in mice colonized with the fungus.The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies.Self-adjuvanting glycopeptide conjugate vaccine against disseminated candidiasis.Fungal vaccines and immunotherapeutics.Elucidating drug resistance in human fungal pathogens.The cross-talk between opportunistic fungi and the mammalian host via microbiota's metabolism.Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice.Prospects for development of a vaccine to prevent and control vaginal candidiasis.Protective immunity against experimental pulmonary cryptococcosis in T cell-depleted mice.Vaccine and monoclonal antibody that enhance mouse resistance to candidiasis Antibodies generated against Streptococci protect in a mouse model of disseminated aspergillosis.Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall.Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice.In vitro inhibitory activity of probiotic products against oral Candida species.Anticandidal immunity and vaginitis: novel opportunities for immune intervention.MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase Vaccines in the treatment of invasive candidiasis.New approaches in the development of a vaccine for mucosal candidiasis: progress and challenges Recent progress in vaccines against fungal diseases Vaccine and immunotherapeutic approaches for the prevention of cryptococcosis: lessons learned from animal models.Synthesis and immunological studies of linear oligosaccharides of β-glucan as antigens for antifungal vaccine development Fungal cell wall vaccines: an update.Progress Toward a Human Vaccine Against Coccidioidomycosis Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection.A Candida albicans mannoprotein deprived of its mannan moiety is efficiently taken up and processed by human dendritic cells and induces T-cell activation without stimulating proinflammatory cytokine production Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis.Hybrid phage displaying SLAQVKYTSASSI induces protection against Candida albicans challenge in BALB/c mice Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new biomarkers of Candida albicans infection that complement tests based on C. albicans mannan.Controlling pathogenic inflammation to fungi.Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection.

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P2860

Advances in combating fungal diseases: vaccines on the threshold

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Nature Reviews Microbiology

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Advances in combating fungal diseases: vaccines on the threshold

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Bruce S Klein

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George S Deepe

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Jim E Cutler

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P2860

Use of licensed vaccines for active immunization of the immunocompromised host

Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display

Prophylactic vaccination with phage-displayed epitope of C. albicans elicits protective immune responses against systemic candidiasis in C57BL/6 mice.

Identification of a protective antigen of Coccidioides immitis by expression library immunization.

Coccidioidomycosis: host response and vaccine development

Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13

Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection.

Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies.

Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis

A vaccine and monoclonal antibodies that enhance mouse resistance to Candida albicans vaginal infection.

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