Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation.
about
Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancersCyclin D as a therapeutic target in cancerAccelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1First insight into the kinome of human regulatory T cells.Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.Targeting cell cycle regulators in hematologic malignancies.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors GranulopoiesisCell cycle and developmental control of hematopoiesis by Runx1.CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia.Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasisIs Runx a linchpin for developmental signaling in metazoans?Post-translational modifications of Runx1 regulate its activity in the cellA role for RUNX1 in hematopoiesis and myeloid leukemia.Posttranslational modifications of RUNX1 as potential anticancer targets.The RUNX family: developmental regulators in cancer.CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation.Runx1 Structure and Function in Blood Cell Development.Covalent Modifications of RUNX Proteins: Structure Affects Function.The core binding factor CBF negatively regulates skeletal muscle terminal differentiationRunt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock.Tyrosyl phosphorylation toggles a Runx1 switch.CDK4/6 blockade in breast cancer: current experience and future perspectives.Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome.
P2860
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P2860
Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Cyclin-dependent kinase phosph ...... stimulates cell proliferation.
@ast
Cyclin-dependent kinase phosph ...... stimulates cell proliferation.
@en
type
label
Cyclin-dependent kinase phosph ...... stimulates cell proliferation.
@ast
Cyclin-dependent kinase phosph ...... stimulates cell proliferation.
@en
prefLabel
Cyclin-dependent kinase phosph ...... stimulates cell proliferation.
@ast
Cyclin-dependent kinase phosph ...... stimulates cell proliferation.
@en
P2093
P2860
P1433
P1476
Cyclin-dependent kinase phosph ...... stimulates cell proliferation.
@en
P2093
Alan D Friedman
Florence B Fried
Linsheng Zhang
P2860
P304
P356
10.1182/BLOOD-2007-08-109702
P407
P577
2007-11-14T00:00:00Z