The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.
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Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune TargetsIntergenically Spliced Chimeric RNAs in Cancer.How do messenger RNA splicing alterations drive myelodysplasia?The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene.Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the IKBKAP gene of familial dysautonomia.A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferationAn alternative splicing program promotes adipose tissue thermogenesisLessons from non-canonical splicingIdentification of protein features encoded by alternative exons using Exon Ontology.Variant in the X-chromosome spliceosomal gene GPKOW causes male-lethal microcephaly with intrauterine growth restriction.The isoflavone fraction from soybean presents mRNA maturation inhibition activity.Pre-mRNA mis-splicing of sarcomeric genes in heart failure.Splicing factor gene mutations in hematologic malignancies.Succession of splicing regulatory elements determines cryptic 5΄ss functionality.Faulty RNA splicing: consequences and therapeutic opportunities in brain and muscle disorders.Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.The emerging role of alternative splicing in senescence and aging.From Cryptic Toward Canonical Pre-mRNA Splicing in Pompe Disease: a Pipeline for the Development of Antisense Oligonucleotides.IKBKAP/ELP1 gene mutations: mechanisms of familial dysautonomia and gene-targeting therapies.Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP.Molecular roles and function of circular RNAs in eukaryotic cells.The contribution of alternative splicing to genetic risk for psychiatric disorders.Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF.Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins.Exon Specific U1 snRNAs improve ELP1 exon 20 definition and rescue ELP1 protein expression in a Familial Dysautonomia mouse model.[Pre-mRNA splicing: when the spliceosome loses ground].SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements.
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P2860
The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
The pathogenicity of splicing ...... novel therapeutic approaches.
@ast
The pathogenicity of splicing ...... novel therapeutic approaches.
@en
type
label
The pathogenicity of splicing ...... novel therapeutic approaches.
@ast
The pathogenicity of splicing ...... novel therapeutic approaches.
@en
prefLabel
The pathogenicity of splicing ...... novel therapeutic approaches.
@ast
The pathogenicity of splicing ...... novel therapeutic approaches.
@en
P2860
P356
P1433
P1476
The pathogenicity of splicing ...... novel therapeutic approaches.
@en
P2093
Elisabeth Daguenet
P2860
P304
P356
10.15252/EMBR.201541116
P577
2015-11-13T00:00:00Z