Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. - Wikidata - wikimedia - TriplyDB

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

http://www.wikidata.org/entity/Q36410748

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Sphingolipids in High Fat Diet and Obesity-Related Diseases Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate Defect of insulin signal in peripheral tissues: Important role of ceramide Bile acid signaling in metabolic disease and drug therapy Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Ceramides and glucosylceramides are independent antagonists of insulin signaling Mitochondrial dysfunction and insulin resistance: an update.Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes Switching the sphingolipid rheostat in the treatment of diabetes and cancer comorbidity from a problem to an advantage.Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes.Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling.Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents.Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance.The role of sphingolipid signalling in diabetes‑associated pathologies (Review).Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology.Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes.Lipid-mediated muscle insulin resistance: different fat, different pathways?Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival.Targeting ceramide metabolism in obesity.A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats.α-Linolenic acid supplementation and exercise training reveal independent and additive responses on hepatic lipid accumulation in obese rats.A pilot study examining the impact of exercise training on skeletal muscle genes related to the TLR signaling pathway in older adults following hip fracture recovery.Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress.Ceramide and insulin resistance: how should the issue be approached?Adiponectin serenades ceramidase to improve metabolism.Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism.Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats.Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance.LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition.The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.

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Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

http://www.wikidata.org/entity/Q36410748

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Overexpression of sphingosine ...... nce in high-fat diet-fed mice.

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Christine Yang

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Clinton R Bruce

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Greg M Kowalski

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Jacquelyn M Weir

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Joanne R Babb

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Kazuaki Yoshioka

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Mark A Febbraio

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Peter J Meikle

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Robert S Lee-Young

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P2860

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Inflammation and metabolic disorders

Principles of bioactive lipid signalling: lessons from sphingolipids

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

A central role for JNK in obesity and insulin resistance

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.

The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice.

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.

A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury.

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