State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit.
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Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptorStructure of a potentially open state of a proton-activated pentameric ligand-gated ion channelOne-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologueThe glial and the neuronal glycine transporters differ in their reactivity to sulfhydryl reagentsChemically charging the pore constriction opens the mechanosensitive channel MscL.Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonistIdentification of a functionally important conformation-sensitive region of the secretory Na+-K+-2Cl- cotransporter (NKCC1)Probing distance and electrical potential within a protein pore with tethered DNAA single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels.Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents.Partitioning of a polymer into a nanoscopic protein pore obeys a simple scaling law.Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptorsM2 pore mutations convert the glycine receptor channel from being anion- to cation-selective.A model of the closed form of the nicotinic acetylcholine receptor m2 channel pore.State-dependent changes in the electrostatic potential in the pore of a GluR channel.Homology model of the GABAA receptor examined using Brownian dynamicsAn energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility methodComputed pore potentials of the nicotinic acetylcholine receptor.Structural effects of quinacrine binding in the open channel of the acetylcholine receptor.An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.Mapping the membrane topography of the TH6-TH7 segment of the diphtheria toxin T-domain channel.The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice.Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations.The location of a closed channel gate in the GABAA receptor channel.The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel.Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels.Location of a constriction in the lumen of a transmembrane pore by targeted covalent attachment of polymer molecules.Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel.Movement and crevices around a sodium channel S3 segment.Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents.Can Shaker potassium channels be locked in the deactivated state?Cysteine mutagenesis reveals novel structure-function features within the predicted third extracellular loop of the type IIa Na(+)/P(i) cotransporterCation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity.Structural signatures and membrane helix 4 in GLUT1: inferences from human blood-brain glucose transport mutantsConformational changes in alpha 7 acetylcholine receptors underlying allosteric modulation by divalent cations.Probing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop.Conformationally sensitive residues in transmembrane domain 9 of the Na+/dicarboxylate co-transporter.
P2860
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P2860
State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
State-dependent accessibility ...... segment of the alpha subunit.
@ast
State-dependent accessibility ...... segment of the alpha subunit.
@en
type
label
State-dependent accessibility ...... segment of the alpha subunit.
@ast
State-dependent accessibility ...... segment of the alpha subunit.
@en
prefLabel
State-dependent accessibility ...... segment of the alpha subunit.
@ast
State-dependent accessibility ...... segment of the alpha subunit.
@en
P2860
P356
P1476
State-dependent accessibility ...... segment of the alpha subunit.
@en
P2093
P2860
P304
P356
10.1085/JGP.111.6.717
P577
1998-06-01T00:00:00Z