Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
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Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersFrom rapalogs to anti-aging formula.Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.Of Cytometry, Stem Cells and Fountain of Youth.SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells.Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiationHow Diet Intervention via Modulation of DNA Damage Response through MicroRNAs May Have an Effect on Cancer Prevention and Aging, an in Silico Study.Accelerated geroncogenesis in hereditary breast-ovarian cancer syndromePreclinical validation of a novel compound targeting p70S6 kinase in breast cancer.Inverse correlation between longevity and developmental rate among wild C. elegans strains.mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancerGerosuppression by pan-mTOR inhibitors.Suppression of PC-1/PrLZ sensitizes prostate cancer cells to ionizing radiation by attenuating DNA damage repair and inducing autophagic cell death.Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer.Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes.mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cellsDual mTORC1/C2 inhibitors: gerosuppressors with potential anti-aging effect.HIF-1α and rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress.Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylationInhibitors of mTOR in aging and cancer.TOR-inhibitors as gero-suppressors.Rapid and simple detection of gero-suppressive agents.Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway.Towards natural mimetics of metformin and rapamycin.Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model.Inhibition of mTOR Signaling Pathway Delays Follicle Formation in Mice.While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts.Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies.
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P2860
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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2015年學術文章
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2015年學術文章
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name
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
@ast
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
@en
type
label
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
@ast
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
@en
prefLabel
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
@ast
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
@en
P2860
P356
P1433
P1476
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
@en
P2093
Olga V Leontieva
Zoya N Demidenko
P2860
P304
23238-23248
P356
10.18632/ONCOTARGET.4836
P407
P577
2015-07-10T00:00:00Z