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The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cellsFerrochelatase is a therapeutic target for ocular neovascularization.Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells.Triptolide as an Alternative to IVIG Therapy for Kawasaki Disease in a Mouse ModelMapping the protein interaction landscape for fully functionalized small-molecule probes in human cells.Identification and validation of protein targets of bioactive small moleculesPhosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts.Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation.Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells.Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.The druggability of intracellular nucleotide-degrading enzymes.Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolideDNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells.Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I.Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin.Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.Triptolide protects podocytes from TGF-β-induced injury by preventing miR-30 downregulation.Critical Role of Hepatic Cyp450s in the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice.Intestinal tract is an important organ for lowering serum uric acid in rats.Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Triptolide directly inhibits dCTP pyrophosphatase.
@ast
Triptolide directly inhibits dCTP pyrophosphatase.
@en
type
label
Triptolide directly inhibits dCTP pyrophosphatase.
@ast
Triptolide directly inhibits dCTP pyrophosphatase.
@en
prefLabel
Triptolide directly inhibits dCTP pyrophosphatase.
@ast
Triptolide directly inhibits dCTP pyrophosphatase.
@en
P2093
P2860
P356
P1433
P1476
Triptolide directly inhibits dCTP pyrophosphatase
@en
P2093
Craig M Crews
Hüseyin Cavga
Nicholas Aberle
P2860
P304
P356
10.1002/CBIC.201100007
P577
2011-06-10T00:00:00Z