Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

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http://www.wikidata.org/entity/Q36425068

Q36425068

about

Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro Tenofovir diphosphate concentrations and prophylactic effect in a macaque model of rectal simian HIV transmission.A cutting-edge view on the current state of antiviral drug development.Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate.Adenine: an important drug scaffold for the design of antiviral agents Antiviral drug resistance and the need for development of new HIV-1 reverse transcriptase inhibitors.Fluorinated Nucleosides: Synthesis and Biological Implication The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys.Novel compounds for the treatment of HIV type-1 infection.Medicinal chemistry of fluorinated cyclic and acyclic nucleoside phosphonates.Tenofovir-induced nephrotoxicity: incidence, mechanism, risk factors, prognosis and proposed agents for prevention.Anti-HIV Nucleoside Phosphonate GS-9148 and Its Prodrug GS-9131: Scale Up of a 2'-F Modified Cyclic Nucleoside Phosphonate and Synthesis of Selected Amidate Prodrugs.Synthesis and Biological Evaluation of 9-Deazaadenine 5'-Deoxy-6',6'-Difluoro-Carbocyclic C-Nucleoside Phosphonic Acid Derivatives.Synthesis of Novel 4'-Trifluoromethyl-5'-Norcarbocyclic C-Nucleoside Phosphonic Acids as Potent Anti-Leukemic Agents.Efficient electrophilic fluorination for the synthesis of novel 2'-fluoro-3'-methyl-5'-deoxyphosphonic acid apiosyl nucleoside analogues.Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.Synthesis of 3'-o-phosphonoethyl nucleosides with an adenine and a thymine base moiety.Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.Synthesis and Anti-HIV Activity of Novel 2'-Deoxy-2'-β-Fluoro-Threosyl Nucleoside Phosphonic Acid Analogues.Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.Synthesis of novel 2',3'-difluorinated 5'-deoxythreosyl phosphonic acid nucleosides as antiviral agents.Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.Synthesis and antiviral evaluation of novel 2',2'-difluoro 5'-norcarbocyclic phosphonic acid nucleosides as antiviral agents.Long-Acting HIV Treatment and Prevention: Closer to the Threshold.Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.Synthesis of novel 4'-cyclopropyl-5'-norcarbocyclic adenosine phosphonic acid analogues.Ten paths to the discovery of antivirally active nucleoside and nucleotide analogues.Synthesis and antiviral evaluation of base-modified deoxythreosyl nucleoside phosphonates.Emerging reverse transcriptase inhibitors for HIV-1 infection.Anti-DNA Virus Agents HIV Reverse Transcriptase Inhibitors Emerging antiviral drugs

P2860

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P2860

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

Item

http://www.wikidata.org/entity/Q36425068

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

@zh-my

2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Design and profiling of GS-914 ...... phonoamidate prodrug, GS-9131.

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Design and profiling of GS-914 ...... phonoamidate prodrug, GS-9131.

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Design and profiling of GS-914 ...... phonoamidate prodrug, GS-9131.

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Design and profiling of GS-914 ...... phonoamidate prodrug, GS-9131.

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Design and profiling of GS-914 ...... phonoamidate prodrug, GS-9131.

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Design and profiling of GS-914 ...... phonoamidate prodrug, GS-9131.

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P1476

Design and profiling of GS-914 ...... sphonoamidate prodrug, GS-9131

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P2093

Anne Carey

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Constantine G Boojamra

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Deborah Grant

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Florence Myrick

http://www.w3.org/2001/XMLSchema#string

Genevieve Laflamme

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Hon Hui

http://www.w3.org/2001/XMLSchema#string

James Chen

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Janet L Douglas

http://www.w3.org/2001/XMLSchema#string

Jennifer E Vela

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Kirsten L White

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P2860

Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia

4'-Ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro

Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA

Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine

Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity.

Mitochondrial toxicity and HIV therapy.

P304

655-665

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scholarly article

P356

10.1128/AAC.01215-07

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English

P433

http://www.w3.org/2001/XMLSchema#string

P478

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Adrian S. Ray

Richard L Mackman

Tomáš Cihlář

P577

2007-12-03T00:00:00Z

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18056282

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2224772

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Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

about

P2860

P2860

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

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P1433

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P356

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P1476

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P407

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P932