Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
about
Targeting Toll-like receptors with small molecule agentsVirtual Screening Approaches towards the Discovery of Toll-Like Receptor ModulatorsHepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in miceProspective virtual screening in a sparse data scenario: design of small-molecule TLR2 antagonists.Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host InsultsThe oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophagesRationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory ResponseTargeting protein-protein interfaces using macrocyclic peptides.Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domainState-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain.Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Drugging Membrane Protein Interactions.Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes.Biological approaches to treating intervertebral disk degeneration: devising stem cell therapies.Expression, Regulation, and Effects of Interleukin-17f in the Human Ocular Surface.Advances in Antiviral Therapies Targeting Toll-like Receptors.Recent progress in the development of Toll-like receptor (TLR) antagonists.Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists.Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates.Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.Regioselective Bromination of Benzocycloheptadienones for the Synthesis of Substituted 3,4-Benzotropolones Including Goupiolone A.Toll-like receptor 2 antagonists identified through virtual screening and experimental validation.Structural Revision and Biomimetic Synthesis of Goupiolone B.Importance of phosphoinositide binding by human β-defensin 3 for Akt-dependent cytokine induction.Amantadine attenuates sepsis-induced cognitive dysfunction possibly not through inhibiting toll-like receptor 2.Expression and regulation of alarmin cytokine IL-1α in human retinal pigment epithelial cells.Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors.Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies.Serum amyloid A primes microglia for ATP-dependent interleukin-1β release.
P2860
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P2860
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
@ast
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
@en
type
label
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
@ast
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
@en
prefLabel
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
@ast
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
@en
P2093
P2860
P356
P1476
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex
@en
P2093
Shuting Zhang
P2860
P304
12246-12249
P356
10.1002/ANIE.201204910
P407
P50
P577
2012-09-11T00:00:00Z